Coordinated regulation of adipose tissue macrophages by cellular and nutritional signals

Daniel Har, Michelle Carey, Meredith A. Hawkins

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The current epidemic of obesity is fueling a global rise in non-communicable diseases, including type 2 diabetes mellitus, atherothrombotic disease, and cancer. Obesity is associated with systemic inflammation, with various fat-derived inflammatory factors being implicated in the pathophysiology of insulin resistance. The infiltration of various types of inflammatory cells into adipose tissue seems to be an important mechanism whereby nutrient excess contributes to systemic insulin resistance. In particular, adipose tissue macrophages are abundant in obese adipose tissue, and may be the source of the majority of fat-derived circulating inflammatory factors. This review examines recent studies exploring mechanisms whereby cellular and nutritional signals mediate macrophage recruitment to adipose tissue and their pro-inflammatory activation.

Original languageEnglish (US)
Pages (from-to)937-941
Number of pages5
JournalJournal of Investigative Medicine
Volume61
Issue number6
DOIs
StatePublished - 2013

Fingerprint

Macrophages
Adipose Tissue
Tissue
Insulin Resistance
Obesity
Fats
Insulin
Fueling
Medical problems
Infiltration
Type 2 Diabetes Mellitus
Nutrients
Chemical activation
Inflammation
Food
Neoplasms

Keywords

  • Cytokines
  • Free fatty acids
  • Regulation of adipose tissue macrophages

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Coordinated regulation of adipose tissue macrophages by cellular and nutritional signals. / Har, Daniel; Carey, Michelle; Hawkins, Meredith A.

In: Journal of Investigative Medicine, Vol. 61, No. 6, 2013, p. 937-941.

Research output: Contribution to journalArticle

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