Controlling the direction of division

Peter Satir

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?.

Original languageEnglish (US)
Article number21
JournalStem Cell Research and Therapy
Volume1
Issue number3
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Cell Biology

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