Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus

Juxue Li, Yizhe Tang, Sudarshana Purkayastha, Jingqi Yan, Dongsheng Cai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Neural stem cells (NSCs) were recently revealed to exist in the hypothalamus of adult mice. Here, following our observation showing that a partial loss of hypothalamic NSCs caused weight gain and glucose intolerance, we studied if NSCs-based cell therapy could be developed to control these disorders. While hypothalamus-implanted NSCs failed to survive in mice with obesity, NF-κB inhibition induced survival and neurogenesis of these cells, leading to effects in counteracting obesity and glucose intolerance. To generate an alternative cell source, we revealed that iPS-derived NSCs were converted into htNSCs by neuropeptide treatment. Of note, obesity condition potentiated the transfer of carotid artery-injected NSCs into the hypothalamus. These iPS-derived cells when engineered with NF-κB inhibition were also effective in reducing obesity and glucose intolerance, and neurogenesis towards POMCergic and GABAergic lineages was accountable. In conclusion, building NSCs in the hypothalamus represents a strategy for controlling obesity and glucose disorders.

Original languageEnglish (US)
Pages (from-to)313-324
Number of pages12
JournalMolecular Metabolism
Volume3
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Glucose Intolerance
Neural Stem Cells
Hypothalamus
Obesity
Neurogenesis
Cell- and Tissue-Based Therapy
Neuropeptides
Carotid Arteries
Weight Gain
Cell Survival
Observation
Glucose

Keywords

  • Glucose tolerance
  • Hypothalamus
  • IPS
  • Neural stem cells
  • Neuropeptide
  • NF-κB
  • Obesity

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus. / Li, Juxue; Tang, Yizhe; Purkayastha, Sudarshana; Yan, Jingqi; Cai, Dongsheng.

In: Molecular Metabolism, Vol. 3, No. 3, 2014, p. 313-324.

Research output: Contribution to journalArticle

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