Control of natural resistance to salmonella typhimurium and leishmania donovani in mice by closely linked but distinct genetic loci

Alison D. O'Brien, David L. Rosenstreich, Benjamin A. Taylor

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Inbred strains of mice vary in their sensitivity to infection with both Salmonella typhimurium1,2 and Leishmania donovani3. In both cases, this differential susceptibility is genetically controlled. Resistance to the intracellularparasite L. donovani is determined by a single locus on chromosome 1, designated Lsh (ref. 4). The primary regulator of resistance to S. typhimurium is a single, dominant autosomal gene, named Ity (for immunity to typhimurium)5, and it has also been recently mapped to chromosome 1 (ref. 6). In addition, two other genetic loci regulate resistance to S. typhimurium in mice. These genes, Lpsd and xid, are mutant alleles that render C3H/HeJ and CBA/N mice, respectively, salmonella susceptible7,8. Both Bradley and his colleagues3,4, and Plant and Glynn2,6, noted similar patterns of resistance or susceptibility of inbred strains of mice to L. donovani and S. typhimurium, and therefore suggested that Lsh and Ity might be the same gene. Mapping of both genes to the same region of chromosome 1 supported this hypothesis but no linkage studies have been used to test it. Since recombinant inbred (RI) mouse strains are, in effect, permanent segregant populations9, they are ideal for determining linkage between resistance genes to two different pathogens. Therefore, we determined the S. typhimurium susceptibility of five sets of RI mouse strains that had been previously typed for Lsh4 and conclude that Lsh and Ity are closely linked but distinct genetic Human B lymphocytes areloci.

Original languageEnglish (US)
Pages (from-to)440-442
Number of pages3
JournalNature
Volume287
Issue number5781
DOIs
StatePublished - 1980

Fingerprint

Leishmania donovani
Inbred Strains Mice
Genetic Loci
Salmonella typhimurium
Innate Immunity
Chromosomes, Human, Pair 1
Immunity
Salmonella
Genes
Dominant Genes
Inbred CBA Mouse
Chromosome Mapping
Leishmania
Medical Genetics
B-Lymphocytes
Alleles
Infection

ASJC Scopus subject areas

  • General

Cite this

Control of natural resistance to salmonella typhimurium and leishmania donovani in mice by closely linked but distinct genetic loci. / O'Brien, Alison D.; Rosenstreich, David L.; Taylor, Benjamin A.

In: Nature, Vol. 287, No. 5781, 1980, p. 440-442.

Research output: Contribution to journalArticle

@article{1758cfc326f747cb9744a3cd78417565,
title = "Control of natural resistance to salmonella typhimurium and leishmania donovani in mice by closely linked but distinct genetic loci",
abstract = "Inbred strains of mice vary in their sensitivity to infection with both Salmonella typhimurium1,2 and Leishmania donovani3. In both cases, this differential susceptibility is genetically controlled. Resistance to the intracellularparasite L. donovani is determined by a single locus on chromosome 1, designated Lsh (ref. 4). The primary regulator of resistance to S. typhimurium is a single, dominant autosomal gene, named Ity (for immunity to typhimurium)5, and it has also been recently mapped to chromosome 1 (ref. 6). In addition, two other genetic loci regulate resistance to S. typhimurium in mice. These genes, Lpsd and xid, are mutant alleles that render C3H/HeJ and CBA/N mice, respectively, salmonella susceptible7,8. Both Bradley and his colleagues3,4, and Plant and Glynn2,6, noted similar patterns of resistance or susceptibility of inbred strains of mice to L. donovani and S. typhimurium, and therefore suggested that Lsh and Ity might be the same gene. Mapping of both genes to the same region of chromosome 1 supported this hypothesis but no linkage studies have been used to test it. Since recombinant inbred (RI) mouse strains are, in effect, permanent segregant populations9, they are ideal for determining linkage between resistance genes to two different pathogens. Therefore, we determined the S. typhimurium susceptibility of five sets of RI mouse strains that had been previously typed for Lsh4 and conclude that Lsh and Ity are closely linked but distinct genetic Human B lymphocytes areloci.",
author = "O'Brien, {Alison D.} and Rosenstreich, {David L.} and Taylor, {Benjamin A.}",
year = "1980",
doi = "10.1038/287440a0",
language = "English (US)",
volume = "287",
pages = "440--442",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5781",

}

TY - JOUR

T1 - Control of natural resistance to salmonella typhimurium and leishmania donovani in mice by closely linked but distinct genetic loci

AU - O'Brien, Alison D.

AU - Rosenstreich, David L.

AU - Taylor, Benjamin A.

PY - 1980

Y1 - 1980

N2 - Inbred strains of mice vary in their sensitivity to infection with both Salmonella typhimurium1,2 and Leishmania donovani3. In both cases, this differential susceptibility is genetically controlled. Resistance to the intracellularparasite L. donovani is determined by a single locus on chromosome 1, designated Lsh (ref. 4). The primary regulator of resistance to S. typhimurium is a single, dominant autosomal gene, named Ity (for immunity to typhimurium)5, and it has also been recently mapped to chromosome 1 (ref. 6). In addition, two other genetic loci regulate resistance to S. typhimurium in mice. These genes, Lpsd and xid, are mutant alleles that render C3H/HeJ and CBA/N mice, respectively, salmonella susceptible7,8. Both Bradley and his colleagues3,4, and Plant and Glynn2,6, noted similar patterns of resistance or susceptibility of inbred strains of mice to L. donovani and S. typhimurium, and therefore suggested that Lsh and Ity might be the same gene. Mapping of both genes to the same region of chromosome 1 supported this hypothesis but no linkage studies have been used to test it. Since recombinant inbred (RI) mouse strains are, in effect, permanent segregant populations9, they are ideal for determining linkage between resistance genes to two different pathogens. Therefore, we determined the S. typhimurium susceptibility of five sets of RI mouse strains that had been previously typed for Lsh4 and conclude that Lsh and Ity are closely linked but distinct genetic Human B lymphocytes areloci.

AB - Inbred strains of mice vary in their sensitivity to infection with both Salmonella typhimurium1,2 and Leishmania donovani3. In both cases, this differential susceptibility is genetically controlled. Resistance to the intracellularparasite L. donovani is determined by a single locus on chromosome 1, designated Lsh (ref. 4). The primary regulator of resistance to S. typhimurium is a single, dominant autosomal gene, named Ity (for immunity to typhimurium)5, and it has also been recently mapped to chromosome 1 (ref. 6). In addition, two other genetic loci regulate resistance to S. typhimurium in mice. These genes, Lpsd and xid, are mutant alleles that render C3H/HeJ and CBA/N mice, respectively, salmonella susceptible7,8. Both Bradley and his colleagues3,4, and Plant and Glynn2,6, noted similar patterns of resistance or susceptibility of inbred strains of mice to L. donovani and S. typhimurium, and therefore suggested that Lsh and Ity might be the same gene. Mapping of both genes to the same region of chromosome 1 supported this hypothesis but no linkage studies have been used to test it. Since recombinant inbred (RI) mouse strains are, in effect, permanent segregant populations9, they are ideal for determining linkage between resistance genes to two different pathogens. Therefore, we determined the S. typhimurium susceptibility of five sets of RI mouse strains that had been previously typed for Lsh4 and conclude that Lsh and Ity are closely linked but distinct genetic Human B lymphocytes areloci.

UR - http://www.scopus.com/inward/record.url?scp=0019175872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019175872&partnerID=8YFLogxK

U2 - 10.1038/287440a0

DO - 10.1038/287440a0

M3 - Article

VL - 287

SP - 440

EP - 442

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5781

ER -