Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity

Genevieve Marcelin, Streamson C. Chua, Jr.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.

Original languageEnglish (US)
Pages (from-to)588-593
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume10
Issue number5
DOIs
StatePublished - Oct 2010

Fingerprint

Lipid Metabolism
Adipocytes
Adipose Tissue
Obesity
Brown Adipocytes
White Adipose Tissue
Lipolysis
Disease Susceptibility
Type 2 Diabetes Mellitus
Triglycerides
Chronic Disease
Cardiovascular Diseases
Fatty Acids
Fats
Lipids
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity. / Marcelin, Genevieve; Chua, Jr., Streamson C.

In: Current Opinion in Pharmacology, Vol. 10, No. 5, 10.2010, p. 588-593.

Research output: Contribution to journalArticle

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