Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity

Genevieve Marcelin, Streamson Chua

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.

Original languageEnglish (US)
Pages (from-to)588-593
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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