Contribution of adipose tissue to health span and longevity

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Abstract

Adipose tissue accounts for approximately 20% (lean) to >50% (in extreme obesity) of body mass and is biologically active through its secretion of numerous peptides and release and storage of nutrients such as free fatty acids. Studies in rodents and humans have revealed that body fat distribution, including visceral fat (VF), subcutaneous (SC) fat and ectopic fat are critical for determining the risk posed by obesity. Specific depletion or expansion of the VF depot using genetic or surgical strategies in animal models has proven to have direct effects on metabolic characteristics and disease risk. In humans, there is compelling evidence that abdominal obesity most strongly predicts mortality risk, while in rats, surgical removal of VF improves mean and maximum life span. There is also growing evidence that fat deposition in ectopic depots such as skeletal muscle and liver can cause lipotoxicity and impair insulin action. Conversely, expansion of SC adipose tissue may confer protection from metabolic derangements by serving as a 'metabolic sink' to limit both systemic lipids and the accrual of visceral and ectopic fat. Treatments targeting the prevention of fat accrual in these harmful depots should be considered as a primary target for improving human health span and longevity.

Original languageEnglish (US)
Title of host publicationBody Composition and Aging
PublisherS. Karger AG
Pages1-19
Number of pages19
Volume37
ISBN (Print)9783805595223, 9783805595216
DOIs
StatePublished - Aug 12 2010

Fingerprint

Intra-Abdominal Fat
Adipose Tissue
Subcutaneous Fat
Fats
Health
Obesity
Body Fat Distribution
Abdominal Obesity
Metabolic Diseases
Nonesterified Fatty Acids
Rodentia
Skeletal Muscle
Animal Models
Insulin
Lipids
Food
Peptides
Mortality
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Contribution of adipose tissue to health span and longevity. / Huffman, Derek M.; Barzilai, Nir.

Body Composition and Aging. Vol. 37 S. Karger AG, 2010. p. 1-19.

Research output: Chapter in Book/Report/Conference proceedingChapter

Huffman, Derek M. ; Barzilai, Nir. / Contribution of adipose tissue to health span and longevity. Body Composition and Aging. Vol. 37 S. Karger AG, 2010. pp. 1-19
@inbook{888d082afc1842e4b4175538e8e256fb,
title = "Contribution of adipose tissue to health span and longevity",
abstract = "Adipose tissue accounts for approximately 20{\%} (lean) to >50{\%} (in extreme obesity) of body mass and is biologically active through its secretion of numerous peptides and release and storage of nutrients such as free fatty acids. Studies in rodents and humans have revealed that body fat distribution, including visceral fat (VF), subcutaneous (SC) fat and ectopic fat are critical for determining the risk posed by obesity. Specific depletion or expansion of the VF depot using genetic or surgical strategies in animal models has proven to have direct effects on metabolic characteristics and disease risk. In humans, there is compelling evidence that abdominal obesity most strongly predicts mortality risk, while in rats, surgical removal of VF improves mean and maximum life span. There is also growing evidence that fat deposition in ectopic depots such as skeletal muscle and liver can cause lipotoxicity and impair insulin action. Conversely, expansion of SC adipose tissue may confer protection from metabolic derangements by serving as a 'metabolic sink' to limit both systemic lipids and the accrual of visceral and ectopic fat. Treatments targeting the prevention of fat accrual in these harmful depots should be considered as a primary target for improving human health span and longevity.",
author = "Huffman, {Derek M.} and Nir Barzilai",
year = "2010",
month = "8",
day = "12",
doi = "10.1159/000319991",
language = "English (US)",
isbn = "9783805595223",
volume = "37",
pages = "1--19",
booktitle = "Body Composition and Aging",
publisher = "S. Karger AG",

}

TY - CHAP

T1 - Contribution of adipose tissue to health span and longevity

AU - Huffman, Derek M.

AU - Barzilai, Nir

PY - 2010/8/12

Y1 - 2010/8/12

N2 - Adipose tissue accounts for approximately 20% (lean) to >50% (in extreme obesity) of body mass and is biologically active through its secretion of numerous peptides and release and storage of nutrients such as free fatty acids. Studies in rodents and humans have revealed that body fat distribution, including visceral fat (VF), subcutaneous (SC) fat and ectopic fat are critical for determining the risk posed by obesity. Specific depletion or expansion of the VF depot using genetic or surgical strategies in animal models has proven to have direct effects on metabolic characteristics and disease risk. In humans, there is compelling evidence that abdominal obesity most strongly predicts mortality risk, while in rats, surgical removal of VF improves mean and maximum life span. There is also growing evidence that fat deposition in ectopic depots such as skeletal muscle and liver can cause lipotoxicity and impair insulin action. Conversely, expansion of SC adipose tissue may confer protection from metabolic derangements by serving as a 'metabolic sink' to limit both systemic lipids and the accrual of visceral and ectopic fat. Treatments targeting the prevention of fat accrual in these harmful depots should be considered as a primary target for improving human health span and longevity.

AB - Adipose tissue accounts for approximately 20% (lean) to >50% (in extreme obesity) of body mass and is biologically active through its secretion of numerous peptides and release and storage of nutrients such as free fatty acids. Studies in rodents and humans have revealed that body fat distribution, including visceral fat (VF), subcutaneous (SC) fat and ectopic fat are critical for determining the risk posed by obesity. Specific depletion or expansion of the VF depot using genetic or surgical strategies in animal models has proven to have direct effects on metabolic characteristics and disease risk. In humans, there is compelling evidence that abdominal obesity most strongly predicts mortality risk, while in rats, surgical removal of VF improves mean and maximum life span. There is also growing evidence that fat deposition in ectopic depots such as skeletal muscle and liver can cause lipotoxicity and impair insulin action. Conversely, expansion of SC adipose tissue may confer protection from metabolic derangements by serving as a 'metabolic sink' to limit both systemic lipids and the accrual of visceral and ectopic fat. Treatments targeting the prevention of fat accrual in these harmful depots should be considered as a primary target for improving human health span and longevity.

UR - http://www.scopus.com/inward/record.url?scp=84925944353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925944353&partnerID=8YFLogxK

U2 - 10.1159/000319991

DO - 10.1159/000319991

M3 - Chapter

SN - 9783805595223

SN - 9783805595216

VL - 37

SP - 1

EP - 19

BT - Body Composition and Aging

PB - S. Karger AG

ER -