Contraceptive testing of vaginal agents in rabbits

Philip E. Castle, Timothy E. Hoen, Kevin J. Whaley, Richard A. Cone

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Development of new vaginal products, such as microbiocides and contraceptives, requires in vivo testing of their effect on fertility. Rabbits, unlike smaller laboratory animals such as rats and mice, which inseminate in the uterus, inseminate vaginally and thus are valuable as animal models for testing vaginal agents for contraceptive effects. Rabbits are inexpensive and easy to handle compared to nonhuman primates, and have frequently been used for testing the effects of vaginal agents on fertility. We review the pertinent literature and report findings that provide guidance for effectively using and improving the rabbit contraceptive model in testing new vaginal products.

Original languageEnglish (US)
Pages (from-to)51-60
Number of pages10
JournalContraception
Volume58
Issue number1
DOIs
StatePublished - Jul 1 1998
Externally publishedYes

Keywords

  • Antifertility
  • Contraception
  • Rabbit
  • Vaginal agents

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Castle, P. E., Hoen, T. E., Whaley, K. J., & Cone, R. A. (1998). Contraceptive testing of vaginal agents in rabbits. Contraception, 58(1), 51-60. https://doi.org/10.1016/S0010-7824(98)00059-6