Contraceptive testing of vaginal agents in rabbits

Philip E. Castle; Timothy E. Hoen; Kevin J. Whaley; Richard A. Cone

doi:10.1016/S0010-7824(98)00059-6

Contraceptive testing of vaginal agents in rabbits

Philip E. Castle, Timothy E. Hoen, Kevin J. Whaley, Richard A. Cone

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Development of new vaginal products, such as microbiocides and contraceptives, requires in vivo testing of their effect on fertility. Rabbits, unlike smaller laboratory animals such as rats and mice, which inseminate in the uterus, inseminate vaginally and thus are valuable as animal models for testing vaginal agents for contraceptive effects. Rabbits are inexpensive and easy to handle compared to nonhuman primates, and have frequently been used for testing the effects of vaginal agents on fertility. We review the pertinent literature and report findings that provide guidance for effectively using and improving the rabbit contraceptive model in testing new vaginal products.

Original language	English (US)
Pages (from-to)	51-60
Number of pages	10
Journal	Contraception
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/S0010-7824(98)00059-6
State	Published - Jul 1998
Externally published	Yes

Keywords

Antifertility
Contraception
Rabbit
Vaginal agents

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/S0010-7824(98)00059-6

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@article{19251bf787d74fae904ecf4867aa7b99,

title = "Contraceptive testing of vaginal agents in rabbits",

abstract = "Development of new vaginal products, such as microbiocides and contraceptives, requires in vivo testing of their effect on fertility. Rabbits, unlike smaller laboratory animals such as rats and mice, which inseminate in the uterus, inseminate vaginally and thus are valuable as animal models for testing vaginal agents for contraceptive effects. Rabbits are inexpensive and easy to handle compared to nonhuman primates, and have frequently been used for testing the effects of vaginal agents on fertility. We review the pertinent literature and report findings that provide guidance for effectively using and improving the rabbit contraceptive model in testing new vaginal products.",

keywords = "Antifertility, Contraception, Rabbit, Vaginal agents",

author = "Castle, {Philip E.} and Hoen, {Timothy E.} and Whaley, {Kevin J.} and Cone, {Richard A.}",

note = "Funding Information: Supported by Grant GM-43873 from the National Institutes of Health, Grants CSA-88-028, CSA-88-36, and CSA-94-152 from the Contraceptive Research and Development Program (CONRAD), Eastern Virginia Medical School, under the cooperative agreement with the US Agency for International Development, and ReProtect, LLC. We appreciate Drs. Thomas R. Moench, Larry Zeitlin, and Ms. Selma M. Soyal for their help in the preparation of this manuscript. We acknowledge Drs. R.E. Chapin, B.H. Vickery, and R.G. Wales for providing additional information presented in this manuscript. Finally, we thank Stuart Olmsted for providing data from recent rabbit fertility experiments. ",

year = "1998",

month = jul,

doi = "10.1016/S0010-7824(98)00059-6",

language = "English (US)",

volume = "58",

pages = "51--60",

journal = "Contraception",

issn = "0010-7824",

publisher = "Elsevier USA",

number = "1",

}

TY - JOUR

T1 - Contraceptive testing of vaginal agents in rabbits

AU - Castle, Philip E.

AU - Hoen, Timothy E.

AU - Whaley, Kevin J.

AU - Cone, Richard A.

N1 - Funding Information: Supported by Grant GM-43873 from the National Institutes of Health, Grants CSA-88-028, CSA-88-36, and CSA-94-152 from the Contraceptive Research and Development Program (CONRAD), Eastern Virginia Medical School, under the cooperative agreement with the US Agency for International Development, and ReProtect, LLC. We appreciate Drs. Thomas R. Moench, Larry Zeitlin, and Ms. Selma M. Soyal for their help in the preparation of this manuscript. We acknowledge Drs. R.E. Chapin, B.H. Vickery, and R.G. Wales for providing additional information presented in this manuscript. Finally, we thank Stuart Olmsted for providing data from recent rabbit fertility experiments.

PY - 1998/7

Y1 - 1998/7

N2 - Development of new vaginal products, such as microbiocides and contraceptives, requires in vivo testing of their effect on fertility. Rabbits, unlike smaller laboratory animals such as rats and mice, which inseminate in the uterus, inseminate vaginally and thus are valuable as animal models for testing vaginal agents for contraceptive effects. Rabbits are inexpensive and easy to handle compared to nonhuman primates, and have frequently been used for testing the effects of vaginal agents on fertility. We review the pertinent literature and report findings that provide guidance for effectively using and improving the rabbit contraceptive model in testing new vaginal products.

AB - Development of new vaginal products, such as microbiocides and contraceptives, requires in vivo testing of their effect on fertility. Rabbits, unlike smaller laboratory animals such as rats and mice, which inseminate in the uterus, inseminate vaginally and thus are valuable as animal models for testing vaginal agents for contraceptive effects. Rabbits are inexpensive and easy to handle compared to nonhuman primates, and have frequently been used for testing the effects of vaginal agents on fertility. We review the pertinent literature and report findings that provide guidance for effectively using and improving the rabbit contraceptive model in testing new vaginal products.

KW - Antifertility

KW - Contraception

KW - Rabbit

KW - Vaginal agents

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Contraceptive testing of vaginal agents in rabbits

Abstract

Keywords

ASJC Scopus subject areas

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