Abstract
Performance of a second itG 68Ge/68Ga generator system and production of 68Ga-DOTATOC and 68Ga-PSMA-HBED-CC were tested over one year as an accompaniment to a previously published study (J Nucl Med. 2016;57:1402–1405). Methods Performance of a 1951 MBq 68Ge/68Ga generator was characterized and the eluate used for preparation of 68Ga-DOTATOC and 68Ga-PSMA-HBED-CC. Weekly elution profiles of 68Ga elution yield and 68Ge breakthrough were determined. Results 68Ga elution yields averaged 82% (61.8–98.4%) and 68Ge breakthrough averaged 0.002% (0.0007% to 0.004%). The radiochemical purities of 68Ga-DOTATOC and 68Ga-PSMA-HBED-CC were determined by HPLC analysis to be > 98% and specific activity was 12.6 and 42 GBq/μmol, respectively. 68Ge contamination in the product was under the detection limit (0.00001%). Final sterile, pyrogen-free formulation of 68Ga-DOTATOC and 68Ga-PSMA-HBED-CC in physiologic saline with 5%–7% ethanol was achieved. Conclusion Performance of a 68Ge/68Ga generator was studied over one year with satisfactory results. The generator eluate was used to synthesize 68Ga-DOTATOC and 68Ga-PSMA-HBED-CC on a routine basis in high purity.
Original language | English (US) |
---|---|
Pages (from-to) | 37-39 |
Number of pages | 3 |
Journal | Nuclear Medicine and Biology |
Volume | 53 |
DOIs | |
State | Published - Oct 2017 |
Externally published | Yes |
Keywords
- DKFZ-PSMA-11
- DOTATOC
- Ga generator
- PSMA-HBED-cc
- itG generator
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research