Construct validation of the dietary inflammatory index among postmenopausal women

Fred K. Tabung; Susan E. Steck; Jiajia Zhang; Yunsheng Ma; Angela D. Liese; Ilir Agalliu; Melanie Hingle; Lifang Hou; Thomas G. Hurley; Li Jiao; Lisa W. Martin; Amy E. Millen; Hannah L. Park; Milagros C. Rosal; James M. Shikany; Nitin Shivappa; Judith K. Ockene; James R. Hebert

doi:10.1016/j.annepidem.2015.03.009

Construct validation of the dietary inflammatory index among postmenopausal women

Fred K. Tabung, Susan E. Steck, Jiajia Zhang, Yunsheng Ma, Angela D. Liese, Ilir Agalliu, Melanie Hingle, Lifang Hou, Thomas G. Hurley, Li Jiao, Lisa W. Martin, Amy E. Millen, Hannah L. Park, Milagros C. Rosal, James M. Shikany, Nitin Shivappa, Judith K. Ockene, James R. Hebert

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

296 Scopus citations

Abstract

Purpose: Many dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a food frequency questionnaire and three inflammatory biomarkers in a subsample of 2567 postmenopausal women in the Women's Health Initiative Observational Study. Methods: We used multiple linear and logistic regression models, controlling for potential confounders, to test whether baseline DII predicted concentrations of interleukin-6, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha receptor 2, or an overall biomarker score combining all three inflammatory biomarkers. Results: The DII was associated with the four biomarkers with beta estimates (95% confidence interval) comparing the highest with lowest DII quintiles as follows: interleukin-6: 1.26 (1.15-1.38), P_trend < .0001; tumor necrosis factor alpha receptor 2: 81.43 (19.15-143.71), P_trend=.004; dichotomized hs-CRP (odds ratio for higher vs. lower hs-CRP): 1.30 (0.97-1.67), P_trend=.34; and the combined inflammatory biomarker score: 0.26 (0.12-0.40), P_trend=.0001. Conclusions: The DII was significantly associated with inflammatory biomarkers. Construct validity of the DII indicates its utility for assessing the inflammatory potential of diet and for expanding its use to include associations with common chronic diseases in future studies.

Original language	English (US)
Pages (from-to)	398-405
Number of pages	8
Journal	Annals of Epidemiology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.annepidem.2015.03.009
State	Published - Jun 1 2015

Keywords

Construct validation
Dietary inflammatory index
Inflammatory biomarkers
Women's Health Initiative

ASJC Scopus subject areas

Epidemiology

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10.1016/j.annepidem.2015.03.009

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Tabung, F. K., Steck, S. E., Zhang, J., Ma, Y., Liese, A. D., Agalliu, I., Hingle, M., Hou, L., Hurley, T. G., Jiao, L., Martin, L. W., Millen, A. E., Park, H. L., Rosal, M. C., Shikany, J. M., Shivappa, N., Ockene, J. K., & Hebert, J. R. (2015). Construct validation of the dietary inflammatory index among postmenopausal women. Annals of Epidemiology, 25(6), 398-405. https://doi.org/10.1016/j.annepidem.2015.03.009

Tabung, FK, Steck, SE, Zhang, J, Ma, Y, Liese, AD, Agalliu, I, Hingle, M, Hou, L, Hurley, TG, Jiao, L, Martin, LW, Millen, AE, Park, HL, Rosal, MC, Shikany, JM, Shivappa, N, Ockene, JK & Hebert, JR 2015, 'Construct validation of the dietary inflammatory index among postmenopausal women', Annals of Epidemiology, vol. 25, no. 6, pp. 398-405. https://doi.org/10.1016/j.annepidem.2015.03.009

@article{229790eb576c42f6be90968732fc9df8,

title = "Construct validation of the dietary inflammatory index among postmenopausal women",

abstract = "Purpose: Many dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a food frequency questionnaire and three inflammatory biomarkers in a subsample of 2567 postmenopausal women in the Women's Health Initiative Observational Study. Methods: We used multiple linear and logistic regression models, controlling for potential confounders, to test whether baseline DII predicted concentrations of interleukin-6, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha receptor 2, or an overall biomarker score combining all three inflammatory biomarkers. Results: The DII was associated with the four biomarkers with beta estimates (95% confidence interval) comparing the highest with lowest DII quintiles as follows: interleukin-6: 1.26 (1.15-1.38), Ptrend < .0001; tumor necrosis factor alpha receptor 2: 81.43 (19.15-143.71), Ptrend=.004; dichotomized hs-CRP (odds ratio for higher vs. lower hs-CRP): 1.30 (0.97-1.67), Ptrend=.34; and the combined inflammatory biomarker score: 0.26 (0.12-0.40), Ptrend=.0001. Conclusions: The DII was significantly associated with inflammatory biomarkers. Construct validity of the DII indicates its utility for assessing the inflammatory potential of diet and for expanding its use to include associations with common chronic diseases in future studies.",

keywords = "Construct validation, Dietary inflammatory index, Inflammatory biomarkers, Women's Health Initiative",

author = "Tabung, {Fred K.} and Steck, {Susan E.} and Jiajia Zhang and Yunsheng Ma and Liese, {Angela D.} and Ilir Agalliu and Melanie Hingle and Lifang Hou and Hurley, {Thomas G.} and Li Jiao and Martin, {Lisa W.} and Millen, {Amy E.} and Park, {Hannah L.} and Rosal, {Milagros C.} and Shikany, {James M.} and Nitin Shivappa and Ockene, {Judith K.} and Hebert, {James R.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc..",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.annepidem.2015.03.009",

language = "English (US)",

volume = "25",

pages = "398--405",

journal = "Annals of Epidemiology",

issn = "1047-2797",

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T1 - Construct validation of the dietary inflammatory index among postmenopausal women

AU - Tabung, Fred K.

AU - Steck, Susan E.

AU - Zhang, Jiajia

AU - Ma, Yunsheng

AU - Liese, Angela D.

AU - Agalliu, Ilir

AU - Hingle, Melanie

AU - Hou, Lifang

AU - Hurley, Thomas G.

AU - Jiao, Li

AU - Martin, Lisa W.

AU - Millen, Amy E.

AU - Park, Hannah L.

AU - Rosal, Milagros C.

AU - Shikany, James M.

AU - Shivappa, Nitin

AU - Ockene, Judith K.

AU - Hebert, James R.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Purpose: Many dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a food frequency questionnaire and three inflammatory biomarkers in a subsample of 2567 postmenopausal women in the Women's Health Initiative Observational Study. Methods: We used multiple linear and logistic regression models, controlling for potential confounders, to test whether baseline DII predicted concentrations of interleukin-6, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha receptor 2, or an overall biomarker score combining all three inflammatory biomarkers. Results: The DII was associated with the four biomarkers with beta estimates (95% confidence interval) comparing the highest with lowest DII quintiles as follows: interleukin-6: 1.26 (1.15-1.38), Ptrend < .0001; tumor necrosis factor alpha receptor 2: 81.43 (19.15-143.71), Ptrend=.004; dichotomized hs-CRP (odds ratio for higher vs. lower hs-CRP): 1.30 (0.97-1.67), Ptrend=.34; and the combined inflammatory biomarker score: 0.26 (0.12-0.40), Ptrend=.0001. Conclusions: The DII was significantly associated with inflammatory biomarkers. Construct validity of the DII indicates its utility for assessing the inflammatory potential of diet and for expanding its use to include associations with common chronic diseases in future studies.

AB - Purpose: Many dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a food frequency questionnaire and three inflammatory biomarkers in a subsample of 2567 postmenopausal women in the Women's Health Initiative Observational Study. Methods: We used multiple linear and logistic regression models, controlling for potential confounders, to test whether baseline DII predicted concentrations of interleukin-6, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha receptor 2, or an overall biomarker score combining all three inflammatory biomarkers. Results: The DII was associated with the four biomarkers with beta estimates (95% confidence interval) comparing the highest with lowest DII quintiles as follows: interleukin-6: 1.26 (1.15-1.38), Ptrend < .0001; tumor necrosis factor alpha receptor 2: 81.43 (19.15-143.71), Ptrend=.004; dichotomized hs-CRP (odds ratio for higher vs. lower hs-CRP): 1.30 (0.97-1.67), Ptrend=.34; and the combined inflammatory biomarker score: 0.26 (0.12-0.40), Ptrend=.0001. Conclusions: The DII was significantly associated with inflammatory biomarkers. Construct validity of the DII indicates its utility for assessing the inflammatory potential of diet and for expanding its use to include associations with common chronic diseases in future studies.

KW - Construct validation

KW - Dietary inflammatory index

KW - Inflammatory biomarkers

KW - Women's Health Initiative

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DO - 10.1016/j.annepidem.2015.03.009

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SN - 1047-2797

VL - 25

SP - 398

EP - 405

JO - Annals of Epidemiology

JF - Annals of Epidemiology

IS - 6

ER -

Construct validation of the dietary inflammatory index among postmenopausal women

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