Considerations on manganese (Mn) treatments for in vitro studies

Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Manganese (Mn) is an environmental risk factor for neuronal dysfunction and neurodegeneration of the basal ganglia and other brain regions. Aberrant brain Mn levels have been linked to manganism, Parkinson's disease (PD), Huntington's disease (HD) and other neurological disorders. Research on the cellular basis of Mn neurotoxicity has relied upon in vitro or non-human model systems. However, an analysis of relevant Mn concentrations for in vitro studies is lacking - and few studies have examined intracellular Mn levels. Here we perform calculations to evaluate in vitro exposure paradigms in relation to relevant in vivo levels of Mn post-exposure.

Original languageEnglish (US)
Pages (from-to)141-142
Number of pages2
JournalNeuroToxicology
Volume41
DOIs
StatePublished - Mar 2014

Keywords

  • Brain concentrations
  • In vitro
  • Manganese
  • Toxicity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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