Considerations on manganese (Mn) treatments for in vitro studies

Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Manganese (Mn) is an environmental risk factor for neuronal dysfunction and neurodegeneration of the basal ganglia and other brain regions. Aberrant brain Mn levels have been linked to manganism, Parkinson's disease (PD), Huntington's disease (HD) and other neurological disorders. Research on the cellular basis of Mn neurotoxicity has relied upon in vitro or non-human model systems. However, an analysis of relevant Mn concentrations for in vitro studies is lacking - and few studies have examined intracellular Mn levels. Here we perform calculations to evaluate in vitro exposure paradigms in relation to relevant in vivo levels of Mn post-exposure.

Original languageEnglish (US)
Pages (from-to)141-142
Number of pages2
JournalNeuroToxicology
Volume41
DOIs
StatePublished - 2014

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Manganese
Brain
Huntington Disease
Basal Ganglia
Nervous System Diseases
Parkinson Disease
In Vitro Techniques
Research

Keywords

  • Brain concentrations
  • In vitro
  • Manganese
  • Toxicity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Considerations on manganese (Mn) treatments for in vitro studies. / Bowman, Aaron B.; Aschner, Michael.

In: NeuroToxicology, Vol. 41, 2014, p. 141-142.

Research output: Contribution to journalArticle

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