TY - JOUR
T1 - Consequences of metabolic and oxidative modifications of cartilage tissue
AU - Hardin, John A.
AU - Cobelli, Neil
AU - Santambrogio, Laura
N1 - Publisher Copyright:
© 2015 Macmillan Publishers Limited.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - A hallmark of chronic metabolic diseases, such as diabetes and metabolic syndrome, and oxidative stress, as occurs in chronic inflammatory and degenerative conditions, is the presence of extensive protein post-Translational modifications, including glycation, glycoxidation, carbonylation and nitrosylation. These modifications have been detected on structural cartilage proteins in joints and intervertebral discs, where they are known to affect protein folding, induce protein aggregation and, ultimately, generate microanatomical changes in the proteoglycan-collagen network that surrounds chondrocytes. Many of these modifications have also been shown to promote oxidative cleavage as well as enzymatically-mediated matrix degradation. Overall, a general picture starts to emerge indicating that biochemical changes in proteins constitute an early event that compromises the anatomical organization and viscoelasticity of cartilage, thereby affecting its ability to sustain pressure and, ultimately, impeding its overall bio-performance.
AB - A hallmark of chronic metabolic diseases, such as diabetes and metabolic syndrome, and oxidative stress, as occurs in chronic inflammatory and degenerative conditions, is the presence of extensive protein post-Translational modifications, including glycation, glycoxidation, carbonylation and nitrosylation. These modifications have been detected on structural cartilage proteins in joints and intervertebral discs, where they are known to affect protein folding, induce protein aggregation and, ultimately, generate microanatomical changes in the proteoglycan-collagen network that surrounds chondrocytes. Many of these modifications have also been shown to promote oxidative cleavage as well as enzymatically-mediated matrix degradation. Overall, a general picture starts to emerge indicating that biochemical changes in proteins constitute an early event that compromises the anatomical organization and viscoelasticity of cartilage, thereby affecting its ability to sustain pressure and, ultimately, impeding its overall bio-performance.
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U2 - 10.1038/nrrheum.2015.70
DO - 10.1038/nrrheum.2015.70
M3 - Review article
C2 - 26034834
AN - SCOPUS:84940604928
SN - 1759-4790
VL - 11
SP - 521
EP - 529
JO - Nature Reviews Rheumatology
JF - Nature Reviews Rheumatology
IS - 9
ER -