Consequences of metabolic and oxidative modifications of cartilage tissue

John A. Hardin, Neil J. Cobelli, Laura Santambrogio

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A hallmark of chronic metabolic diseases, such as diabetes and metabolic syndrome, and oxidative stress, as occurs in chronic inflammatory and degenerative conditions, is the presence of extensive protein post-Translational modifications, including glycation, glycoxidation, carbonylation and nitrosylation. These modifications have been detected on structural cartilage proteins in joints and intervertebral discs, where they are known to affect protein folding, induce protein aggregation and, ultimately, generate microanatomical changes in the proteoglycan-collagen network that surrounds chondrocytes. Many of these modifications have also been shown to promote oxidative cleavage as well as enzymatically-mediated matrix degradation. Overall, a general picture starts to emerge indicating that biochemical changes in proteins constitute an early event that compromises the anatomical organization and viscoelasticity of cartilage, thereby affecting its ability to sustain pressure and, ultimately, impeding its overall bio-performance.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalNature Reviews Rheumatology
Volume11
Issue number9
DOIs
StatePublished - Oct 1 2015

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Cartilage
Proteins
Intervertebral Disc
Protein Folding
Metabolic Diseases
Proteoglycans
Post Translational Protein Processing
Chondrocytes
Oxidative Stress
Chronic Disease
Collagen
Joints
Pressure

ASJC Scopus subject areas

  • Rheumatology

Cite this

Consequences of metabolic and oxidative modifications of cartilage tissue. / Hardin, John A.; Cobelli, Neil J.; Santambrogio, Laura.

In: Nature Reviews Rheumatology, Vol. 11, No. 9, 01.10.2015, p. 521-529.

Research output: Contribution to journalArticle

Hardin, John A. ; Cobelli, Neil J. ; Santambrogio, Laura. / Consequences of metabolic and oxidative modifications of cartilage tissue. In: Nature Reviews Rheumatology. 2015 ; Vol. 11, No. 9. pp. 521-529.
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