Consequences of metabolic and oxidative modifications of cartilage tissue

John A. Hardin, Neil Cobelli, Laura Santambrogio

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


A hallmark of chronic metabolic diseases, such as diabetes and metabolic syndrome, and oxidative stress, as occurs in chronic inflammatory and degenerative conditions, is the presence of extensive protein post-Translational modifications, including glycation, glycoxidation, carbonylation and nitrosylation. These modifications have been detected on structural cartilage proteins in joints and intervertebral discs, where they are known to affect protein folding, induce protein aggregation and, ultimately, generate microanatomical changes in the proteoglycan-collagen network that surrounds chondrocytes. Many of these modifications have also been shown to promote oxidative cleavage as well as enzymatically-mediated matrix degradation. Overall, a general picture starts to emerge indicating that biochemical changes in proteins constitute an early event that compromises the anatomical organization and viscoelasticity of cartilage, thereby affecting its ability to sustain pressure and, ultimately, impeding its overall bio-performance.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalNature Reviews Rheumatology
Issue number9
StatePublished - Oct 1 2015

ASJC Scopus subject areas

  • Rheumatology


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