Connexins and disease

Mario Delmar, Dale W. Laird, Christian C. Naus, Morten S. Nielsen, Vytautas K. Verselis, Thomas W. White

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia (ODDD). Although incomplete by virtue of space and the extent of the topic, this review emphasizes the fact that connexin function is not only associated with gap junction channel formation. As such, both canonical and noncanonical functions of connexins are fundamental components in the pathophysiology of multiple connexin related disorders, many of them highly debilitating and life threatening. Improved understanding of connexin biology has the potential to advance our understanding of mechanisms, diagnosis, and treatment of disease.

Original languageEnglish (US)
Article numbera029348
JournalCold Spring Harbor Perspectives in Biology
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Delmar, M., Laird, D. W., Naus, C. C., Nielsen, M. S., Verselis, V. K., & White, T. W. (2018). Connexins and disease. Cold Spring Harbor Perspectives in Biology, 10(9), [a029348]. https://doi.org/10.1101/cshperspect.a029348