Connexin43 and the brain transcriptome of newborn mice

Dumitru A. Iacobas, Sanda Iacobas, David C. Spray

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Our previously reported cDNA array datasets from neonatal wild-type and Cx43-/- (approved gene symbol Gja1) mouse brains were further analyzed to identify underlying interlinkages in the brain transcriptome. The analysis revealed that no gene cohort sharing either primary function or chromosomal location was significantly altered (up-and down-regulation were roughly balanced) in Cx43-/- brains, but each cohort exhibited significant perturbation of transcript abundance proportions and reduced expression variability and coordination. By comparing pairwise expression correlations of all genes with one another in wild-type brains, we found genes exhibiting remarkable similarity or opposition to the coordination profile (set of synergistically, antagonistically, and independently expressed partners) of Cx43, one of the most similar being pannexin1, a vertebrate homolog of invertebrate gap junction proteins. This study indicates striking redundancy of expression controls over functional pathways and suggests that certain genes may play roles similar to or opposite that of Cx43 in organizing the brain transcriptome.

Original languageEnglish (US)
Pages (from-to)113-123
Number of pages11
JournalGenomics
Volume89
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Connexin
  • Cx43
  • Gap junction
  • Gja1
  • Pannexin
  • Panx1

ASJC Scopus subject areas

  • Genetics

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