Connecting genes to brain in the autism spectrum disorders

Brett S. Abrahams, Daniel H. Geschwind

Research output: Contribution to journalReview article

116 Scopus citations

Abstract

The autism spectrum disorders (ASDs) are a complex group of neuropsychiatric conditions involving language, social communication, and mental flexibility. Here, we attempt to place recent genetic advances within a developmental and anatomical context. Recent progress in identifying ASD candidate genes supports involvement of multiple brain regions, including the frontal lobes, anterior temporal lobes, caudate, and cerebellum. Understanding genetic data within an anatomical context will be critical to explain how individual risk factors operate to shape phenotypic presentation in patients.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalArchives of Neurology
Volume67
Issue number4
DOIs
Publication statusPublished - Apr 1 2010

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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