Condylomatous genital lesions in cynomolgus macaques from Mauritius

Ariana Harari, Charles E. Wood, Koenraad Van Doorslaer, Zigui Chen, Marie Claire Domaingue, David Elmore, Patricia Koenig, Janice D. Wagner, Ryan N. Jennings, Robert D. Burk

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Genital condyloma-like lesions were observed on male and female cynomolgus macaque monkeys (Macaca fascicularis) originating from the island of Mauritius. Cytobrush and/or biopsy samples were obtained from lesions of 57 affected macaques. Primary histologic features included eosinophilic, neutrophilic, and lymphoplasmacytic penile and vulvar inflammation, epidermal hyperplasia with acanthosis, and increased collagenous stroma. Polymerase chain reaction-based assays to amplify viral DNA revealed the presence of macaque lymphocryptovirus (LCV) DNA but not papillomavirus or poxvirus DNA. Subsequent DNA analyses of 3 genomic regions of LCV identified isolates associated with lesions in 19/25 (76%) biopsies and 19/57 (33%) cytology samples. Variable immunolabeling for proteins related to the human LCV Epstein Barr Virus was observed within intralesional plasma cells, stromal cells, and epithelial cells. Further work is needed to characterize the epidemiologic features of these lesions and their association with LCV infection in Mauritian-origin macaques.

Original languageEnglish (US)
Pages (from-to)893-901
Number of pages9
JournalToxicologic Pathology
Volume41
Issue number6
DOIs
StatePublished - Aug 2013

Fingerprint

Lymphocryptovirus
Mauritius
Macaca
Biopsy
Macaca fascicularis
DNA
Cytology
Polymerase chain reaction
Viral DNA
Poxviridae
Viruses
Assays
Stromal Cells
Plasma Cells
Human Herpesvirus 4
Islands
Association reactions
Hyperplasia
Cell Biology
Plasmas

Keywords

  • condyloma
  • gammaherpesvirus
  • genital
  • lymphocryptovirus
  • macaque
  • Mauritius
  • papillomavirus
  • primate

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology
  • Molecular Biology

Cite this

Harari, A., Wood, C. E., Van Doorslaer, K., Chen, Z., Domaingue, M. C., Elmore, D., ... Burk, R. D. (2013). Condylomatous genital lesions in cynomolgus macaques from Mauritius. Toxicologic Pathology, 41(6), 893-901. https://doi.org/10.1177/0192623312467521

Condylomatous genital lesions in cynomolgus macaques from Mauritius. / Harari, Ariana; Wood, Charles E.; Van Doorslaer, Koenraad; Chen, Zigui; Domaingue, Marie Claire; Elmore, David; Koenig, Patricia; Wagner, Janice D.; Jennings, Ryan N.; Burk, Robert D.

In: Toxicologic Pathology, Vol. 41, No. 6, 08.2013, p. 893-901.

Research output: Contribution to journalArticle

Harari, A, Wood, CE, Van Doorslaer, K, Chen, Z, Domaingue, MC, Elmore, D, Koenig, P, Wagner, JD, Jennings, RN & Burk, RD 2013, 'Condylomatous genital lesions in cynomolgus macaques from Mauritius', Toxicologic Pathology, vol. 41, no. 6, pp. 893-901. https://doi.org/10.1177/0192623312467521
Harari A, Wood CE, Van Doorslaer K, Chen Z, Domaingue MC, Elmore D et al. Condylomatous genital lesions in cynomolgus macaques from Mauritius. Toxicologic Pathology. 2013 Aug;41(6):893-901. https://doi.org/10.1177/0192623312467521
Harari, Ariana ; Wood, Charles E. ; Van Doorslaer, Koenraad ; Chen, Zigui ; Domaingue, Marie Claire ; Elmore, David ; Koenig, Patricia ; Wagner, Janice D. ; Jennings, Ryan N. ; Burk, Robert D. / Condylomatous genital lesions in cynomolgus macaques from Mauritius. In: Toxicologic Pathology. 2013 ; Vol. 41, No. 6. pp. 893-901.
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