Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1

Anna Milanesi, Run Yu, Stephen A. Geller, Doug Burton, Leonard J. Deftos, Edward M. Wolin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report a patient with multiple endocrine neoplasia type 1 presenting with elevation of parathyroid hormone-related protein (PTHrP) from a metastatic pancreatic neuroendocrine tumor (PNET), and parathyroid hormone (PTH) from primary hyperparathyroidism, resulting in severe hypercalcemia. Parathyroid hormone-related protein production by the PNET was confirmed by immunohistochemical analysis. Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis. Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications.

Original languageEnglish (US)
Pages (from-to)634-637
Number of pages4
JournalPancreas
Volume40
Issue number4
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Multiple Endocrine Neoplasia Type 1
Parathyroid Hormone-Related Protein
Primary Hyperparathyroidism
Neuroendocrine Tumors
Hypercalcemia
Parathyroid Hormone
Hepatic Artery
Neoplasm Metastasis
Humoral Hypercalcemia Of Malignancy
Liver
Neoplasms

Keywords

  • hypercalcemia
  • multiple endocrine neoplasia 1
  • pancreatic neuroendocrine tumor
  • parathyroid hormone
  • Parathyroid hormoneYrelated peptide
  • primary hyperparathyroidism

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1. / Milanesi, Anna; Yu, Run; Geller, Stephen A.; Burton, Doug; Deftos, Leonard J.; Wolin, Edward M.

In: Pancreas, Vol. 40, No. 4, 05.2011, p. 634-637.

Research output: Contribution to journalArticle

Milanesi, Anna ; Yu, Run ; Geller, Stephen A. ; Burton, Doug ; Deftos, Leonard J. ; Wolin, Edward M. / Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1. In: Pancreas. 2011 ; Vol. 40, No. 4. pp. 634-637.
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