Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1

Anna Milanesi, Run Yu, Stephen A. Geller, Doug Burton, Leonard J. Deftos, Edward M. Wolin

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report a patient with multiple endocrine neoplasia type 1 presenting with elevation of parathyroid hormone-related protein (PTHrP) from a metastatic pancreatic neuroendocrine tumor (PNET), and parathyroid hormone (PTH) from primary hyperparathyroidism, resulting in severe hypercalcemia. Parathyroid hormone-related protein production by the PNET was confirmed by immunohistochemical analysis. Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis. Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications.

Original languageEnglish (US)
Pages (from-to)634-637
Number of pages4
JournalPancreas
Volume40
Issue number4
DOIs
StatePublished - May 1 2011

Keywords

  • Parathyroid hormoneYrelated peptide
  • hypercalcemia
  • multiple endocrine neoplasia 1
  • pancreatic neuroendocrine tumor
  • parathyroid hormone
  • primary hyperparathyroidism

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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