Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1

Anna Milanesi; Run Yu; Stephen A. Geller; Doug Burton; Leonard J. Deftos; Edward M. Wolin

doi:10.1097/MPA.0b013e318214f65e

Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1

Anna Milanesi, Run Yu, Stephen A. Geller, Doug Burton, Leonard J. Deftos, Edward M. Wolin

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report a patient with multiple endocrine neoplasia type 1 presenting with elevation of parathyroid hormone-related protein (PTHrP) from a metastatic pancreatic neuroendocrine tumor (PNET), and parathyroid hormone (PTH) from primary hyperparathyroidism, resulting in severe hypercalcemia. Parathyroid hormone-related protein production by the PNET was confirmed by immunohistochemical analysis. Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis. Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications.

Original language	English (US)
Pages (from-to)	634-637
Number of pages	4
Journal	Pancreas
Volume	40
Issue number	4
DOIs	https://doi.org/10.1097/MPA.0b013e318214f65e
State	Published - May 2011
Externally published	Yes

Keywords

Parathyroid hormoneYrelated peptide
hypercalcemia
multiple endocrine neoplasia 1
pancreatic neuroendocrine tumor
parathyroid hormone
primary hyperparathyroidism

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MPA.0b013e318214f65e

Cite this

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title = "Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1",

abstract = "We report a patient with multiple endocrine neoplasia type 1 presenting with elevation of parathyroid hormone-related protein (PTHrP) from a metastatic pancreatic neuroendocrine tumor (PNET), and parathyroid hormone (PTH) from primary hyperparathyroidism, resulting in severe hypercalcemia. Parathyroid hormone-related protein production by the PNET was confirmed by immunohistochemical analysis. Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis. Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications.",

keywords = "Parathyroid hormoneYrelated peptide, hypercalcemia, multiple endocrine neoplasia 1, pancreatic neuroendocrine tumor, parathyroid hormone, primary hyperparathyroidism",

author = "Anna Milanesi and Run Yu and Geller, {Stephen A.} and Doug Burton and Deftos, {Leonard J.} and Wolin, {Edward M.}",

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language = "English (US)",

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T1 - Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1

AU - Milanesi, Anna

AU - Yu, Run

AU - Geller, Stephen A.

AU - Burton, Doug

AU - Deftos, Leonard J.

AU - Wolin, Edward M.

PY - 2011/5

Y1 - 2011/5

N2 - We report a patient with multiple endocrine neoplasia type 1 presenting with elevation of parathyroid hormone-related protein (PTHrP) from a metastatic pancreatic neuroendocrine tumor (PNET), and parathyroid hormone (PTH) from primary hyperparathyroidism, resulting in severe hypercalcemia. Parathyroid hormone-related protein production by the PNET was confirmed by immunohistochemical analysis. Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis. Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications.

AB - We report a patient with multiple endocrine neoplasia type 1 presenting with elevation of parathyroid hormone-related protein (PTHrP) from a metastatic pancreatic neuroendocrine tumor (PNET), and parathyroid hormone (PTH) from primary hyperparathyroidism, resulting in severe hypercalcemia. Parathyroid hormone-related protein production by the PNET was confirmed by immunohistochemical analysis. Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis. Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications.

KW - Parathyroid hormoneYrelated peptide

KW - hypercalcemia

KW - multiple endocrine neoplasia 1

KW - pancreatic neuroendocrine tumor

KW - parathyroid hormone

KW - primary hyperparathyroidism

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Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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