Concise review: Hematopoietic stem cell origins: Lessons from embryogenesis for improving regenerative medicine

Adriana De La Garza, Arpan Sinha, Teresa V. Bowman

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone marrow transplantation. Finding appropriate donors remains a major limitation to more extensive usage of HSC-based therapies. Derivation of patient-specific HSCs from pluripotent stem cells offers great promise to remedy this problem if scientists could crack the code on how to make robust, transplantable HSCs in a dish. Studies delving into the native origins of HSC production during embryonic development should supply the necessary play-book. This review presents recent discoveries from animal models, with a focus on zebrafish, and discusses the implications of these new advances in the context of prior knowledge. The focus is on the latest research exploring the role of epigenetic regulation, signaling pathways, and niche components needed for proper HSC formation. These studies provide new directions that should be explored for de novo generation and expansion of HSCs for regenerative therapies.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalStem Cells Translational Medicine
Volume6
Issue number1
DOIs
StatePublished - Jan 2017

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Keywords

  • Bone marrow transplant
  • Developmental biology
  • Embryo
  • Hematopoietic stem cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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