Concise review

Hematopoietic stem cell origins: Lessons from embryogenesis for improving regenerative medicine

Adriana De La Garza, Arpan Sinha, Teresa V. Bowman

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone marrow transplantation. Finding appropriate donors remains a major limitation to more extensive usage of HSC-based therapies. Derivation of patient-specific HSCs from pluripotent stem cells offers great promise to remedy this problem if scientists could crack the code on how to make robust, transplantable HSCs in a dish. Studies delving into the native origins of HSC production during embryonic development should supply the necessary play-book. This review presents recent discoveries from animal models, with a focus on zebrafish, and discusses the implications of these new advances in the context of prior knowledge. The focus is on the latest research exploring the role of epigenetic regulation, signaling pathways, and niche components needed for proper HSC formation. These studies provide new directions that should be explored for de novo generation and expansion of HSCs for regenerative therapies.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalStem cells translational medicine
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Regenerative Medicine
Hematopoietic Stem Cells
Embryonic Development
Cell- and Tissue-Based Therapy
Pluripotent Stem Cells
Zebrafish
Bone Marrow Transplantation
Epigenomics
Blood Cells
Animal Models
Tissue Donors
Research

Keywords

  • Bone marrow transplant
  • Developmental biology
  • Embryo
  • Hematopoietic stem cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Concise review : Hematopoietic stem cell origins: Lessons from embryogenesis for improving regenerative medicine. / De La Garza, Adriana; Sinha, Arpan; Bowman, Teresa V.

In: Stem cells translational medicine, Vol. 6, No. 1, 01.01.2017, p. 60-67.

Research output: Contribution to journalReview article

@article{f620f71cbbf0460ca15d39f38765f186,
title = "Concise review: Hematopoietic stem cell origins: Lessons from embryogenesis for improving regenerative medicine",
abstract = "Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone marrow transplantation. Finding appropriate donors remains a major limitation to more extensive usage of HSC-based therapies. Derivation of patient-specific HSCs from pluripotent stem cells offers great promise to remedy this problem if scientists could crack the code on how to make robust, transplantable HSCs in a dish. Studies delving into the native origins of HSC production during embryonic development should supply the necessary play-book. This review presents recent discoveries from animal models, with a focus on zebrafish, and discusses the implications of these new advances in the context of prior knowledge. The focus is on the latest research exploring the role of epigenetic regulation, signaling pathways, and niche components needed for proper HSC formation. These studies provide new directions that should be explored for de novo generation and expansion of HSCs for regenerative therapies.",
keywords = "Bone marrow transplant, Developmental biology, Embryo, Hematopoietic stem cells",
author = "{De La Garza}, Adriana and Arpan Sinha and Bowman, {Teresa V.}",
year = "2017",
month = "1",
day = "1",
doi = "10.5966/sctm.2016-0110",
language = "English (US)",
volume = "6",
pages = "60--67",
journal = "Stem cells translational medicine",
issn = "2157-6564",
publisher = "AlphaMed Press",
number = "1",

}

TY - JOUR

T1 - Concise review

T2 - Hematopoietic stem cell origins: Lessons from embryogenesis for improving regenerative medicine

AU - De La Garza, Adriana

AU - Sinha, Arpan

AU - Bowman, Teresa V.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone marrow transplantation. Finding appropriate donors remains a major limitation to more extensive usage of HSC-based therapies. Derivation of patient-specific HSCs from pluripotent stem cells offers great promise to remedy this problem if scientists could crack the code on how to make robust, transplantable HSCs in a dish. Studies delving into the native origins of HSC production during embryonic development should supply the necessary play-book. This review presents recent discoveries from animal models, with a focus on zebrafish, and discusses the implications of these new advances in the context of prior knowledge. The focus is on the latest research exploring the role of epigenetic regulation, signaling pathways, and niche components needed for proper HSC formation. These studies provide new directions that should be explored for de novo generation and expansion of HSCs for regenerative therapies.

AB - Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood cell types, an ability that is harnessed in the clinic for bone marrow transplantation. Finding appropriate donors remains a major limitation to more extensive usage of HSC-based therapies. Derivation of patient-specific HSCs from pluripotent stem cells offers great promise to remedy this problem if scientists could crack the code on how to make robust, transplantable HSCs in a dish. Studies delving into the native origins of HSC production during embryonic development should supply the necessary play-book. This review presents recent discoveries from animal models, with a focus on zebrafish, and discusses the implications of these new advances in the context of prior knowledge. The focus is on the latest research exploring the role of epigenetic regulation, signaling pathways, and niche components needed for proper HSC formation. These studies provide new directions that should be explored for de novo generation and expansion of HSCs for regenerative therapies.

KW - Bone marrow transplant

KW - Developmental biology

KW - Embryo

KW - Hematopoietic stem cells

UR - http://www.scopus.com/inward/record.url?scp=85017364900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017364900&partnerID=8YFLogxK

U2 - 10.5966/sctm.2016-0110

DO - 10.5966/sctm.2016-0110

M3 - Review article

VL - 6

SP - 60

EP - 67

JO - Stem cells translational medicine

JF - Stem cells translational medicine

SN - 2157-6564

IS - 1

ER -