Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia

R. S. Goland, P. J. Tropper, W. B. Warren, R. I. Stark, S. M. Jozak, I. M. Conwell

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

The effect of pre-eclampsia on concentrations of corticotrophin releasing hormone (CRH) in umbilical-cord blood of fetuses at delivery was studied in order to determine if fetal CRH is elevated in this disorder when compared with uncomplicated pregnancy. Placental CRH may be a regulator of fetal pituitary-adrenal function and we therefore also measured ACTH, cortisol and dehydroepiandrosterone sulfate (DHEAS) in the umbilical-cord blood. The mean umbilical-cord plasma CRH in the fetuses from pregnancies complicated by pre-eclampsia, 667 ± 153 pg mL-1, was significantly higher than the plasma CRH in the fetuses from normotensive pregnancies, 185 ± 22 pg mL-1 (P < 0.001). The mean fetal cortisol concentration was significantly higher in pre-eclampsia, than in the normotensive, pregnancies (pre-eclampsia, 13.5 ± 1.8; normotensive, 7.6 ± 1.3 μg dL-1; P < 0.001). Plasma DHEAS was 217 ± 23 μg dL-1 in the umbilical-cord blood of the fetuses from pregnancies complicated by pre-eclampsia and 281 ± 35 μg dL-1 in the normotensive pregnancies (P < 0.01). Placental CRH synthesis and release, in contrast to hypothalamic CRH, appears to be stimulated by glucocorticoids. In pregnancies complicated by uteroplacental insufficiency, as may occur in pre-eclampsia, placental CRH production may be enhanced by increased fetal glucocorticoids. In turn, placental CRH may modulate fetal pituitary-adrenal steroidogenesis to favour increased cortisol secretion. Thus, placental CRH may play an important role in the fetal response to a compromised intrauterine environment.

Original languageEnglish (US)
Pages (from-to)1227-1230
Number of pages4
JournalReproduction, Fertility and Development
Volume7
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

pre-eclampsia
corticotropin-releasing hormone
umbilical cord
Corticotropin-Releasing Hormone
Pre-Eclampsia
Fetal Blood
placental hormones
Placental Hormones
pregnancy
Pregnancy
blood
fetus
Fetus
cortisol
prasterone
Dehydroepiandrosterone Sulfate
glucocorticoids
Glucocorticoids
Hydrocortisone
hypothalamic hormones

Keywords

  • adrenal
  • corticotropin releasing hormone (CRH)
  • cortisol
  • fetus
  • pituitary
  • placenta

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Reproductive Medicine
  • Developmental Biology
  • Endocrinology

Cite this

Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia. / Goland, R. S.; Tropper, P. J.; Warren, W. B.; Stark, R. I.; Jozak, S. M.; Conwell, I. M.

In: Reproduction, Fertility and Development, Vol. 7, No. 5, 1995, p. 1227-1230.

Research output: Contribution to journalArticle

Goland, R. S. ; Tropper, P. J. ; Warren, W. B. ; Stark, R. I. ; Jozak, S. M. ; Conwell, I. M. / Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia. In: Reproduction, Fertility and Development. 1995 ; Vol. 7, No. 5. pp. 1227-1230.
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