Concealed cardiomyopathies in competitive athletes with ventricular arrhythmias and an apparently normal heart

Role of cardiac electroanatomical mapping and biopsy

Antonio Dello Russo, Maurizio Pieroni, Pasquale Santangeli, Stefano Bartoletti, Michela Casella, Gemma Pelargonio, Costantino Smaldone, Massimiliano Bianco, Luigi Di Biase, Fulvio Bellocci, Paolo Zeppilli, Cesare Fiorentini, Andrea Natale, Claudio Tondo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: The diagnosis of subtle structural heart disease in competitive athletes with ventricular arrhythmias (VAs) and an apparently normal heart is challenging. Three-dimensional electroanatomic mapping (EAM) has been demonstrated to reliably identify low-voltage areas that correspond to different cardiomyopathic substrates. Objective: The purpose of this study was to test whether EAM may help in the diagnosis of concealed cardiomyopathies in athletes with VAs and an apparently normal heart. Methods: We studied 13 consecutive competitive athletes (12 males, age 30 ± 13 years) who had documentation of VAs within the previous 6 months on 12-lead electrocardiogram (ECG), 24-hour Holter ECG, or ECG exercise testing and who were judged as having a structurally normal heart after a thorough noninvasive evaluation, including signal-averaged ECG, transthoracic echocardiogram, and cardiac magnetic resonance imaging. Depending on the presumed site of VA origin according to 12-lead ECG criteria, patients underwent right or left ventricular EAM and EAM-guided endomyocardial biopsy. Results: Presenting arrhythmias included sustained ventricular tachycardia (n = 3), multiple episodes of nonsustained ventricular tachycardia (n = 7), and frequent ventricular ectopic beats (>1,000 during 24 hours; n = 3). Three patients had a history of syncope. Twelve (92%) patients had at least one low-voltage region at EAM, which corresponded at EAM-guided endomyocardial biopsy to the histological diagnosis of active myocarditis in seven patients and of arrhythmogenic right ventricular cardiomyopathy in five. In one patient the histological evidence of contraction band necrosis allowed the unmasking of caffeine and ephedrine abuse. Conclusions: Electroanatomical substrate mapping may help diagnose concealed myocardial diseases in competitive athletes presenting with recent-onset VAs and an apparently normal heart. Further studies are warranted to assess the prognostic implications of such subtle myocardial abnormalities.

Original languageEnglish (US)
Pages (from-to)1915-1922
Number of pages8
JournalHeart Rhythm
Volume8
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Cardiomyopathies
Athletes
Cardiac Arrhythmias
Electrocardiography
Biopsy
Patient Rights
Ventricular Tachycardia
Arrhythmogenic Right Ventricular Dysplasia
Ventricular Premature Complexes
Myocarditis
Syncope
Documentation
Heart Diseases
Necrosis
Magnetic Resonance Imaging
Exercise

Keywords

  • Arrhythmogenic right ventricular cardiomyopathy
  • Athletes
  • Myocarditis
  • Normal heart
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Concealed cardiomyopathies in competitive athletes with ventricular arrhythmias and an apparently normal heart : Role of cardiac electroanatomical mapping and biopsy. / Dello Russo, Antonio; Pieroni, Maurizio; Santangeli, Pasquale; Bartoletti, Stefano; Casella, Michela; Pelargonio, Gemma; Smaldone, Costantino; Bianco, Massimiliano; Di Biase, Luigi; Bellocci, Fulvio; Zeppilli, Paolo; Fiorentini, Cesare; Natale, Andrea; Tondo, Claudio.

In: Heart Rhythm, Vol. 8, No. 12, 12.2011, p. 1915-1922.

Research output: Contribution to journalArticle

Dello Russo, A, Pieroni, M, Santangeli, P, Bartoletti, S, Casella, M, Pelargonio, G, Smaldone, C, Bianco, M, Di Biase, L, Bellocci, F, Zeppilli, P, Fiorentini, C, Natale, A & Tondo, C 2011, 'Concealed cardiomyopathies in competitive athletes with ventricular arrhythmias and an apparently normal heart: Role of cardiac electroanatomical mapping and biopsy', Heart Rhythm, vol. 8, no. 12, pp. 1915-1922. https://doi.org/10.1016/j.hrthm.2011.07.021
Dello Russo, Antonio ; Pieroni, Maurizio ; Santangeli, Pasquale ; Bartoletti, Stefano ; Casella, Michela ; Pelargonio, Gemma ; Smaldone, Costantino ; Bianco, Massimiliano ; Di Biase, Luigi ; Bellocci, Fulvio ; Zeppilli, Paolo ; Fiorentini, Cesare ; Natale, Andrea ; Tondo, Claudio. / Concealed cardiomyopathies in competitive athletes with ventricular arrhythmias and an apparently normal heart : Role of cardiac electroanatomical mapping and biopsy. In: Heart Rhythm. 2011 ; Vol. 8, No. 12. pp. 1915-1922.
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abstract = "Background: The diagnosis of subtle structural heart disease in competitive athletes with ventricular arrhythmias (VAs) and an apparently normal heart is challenging. Three-dimensional electroanatomic mapping (EAM) has been demonstrated to reliably identify low-voltage areas that correspond to different cardiomyopathic substrates. Objective: The purpose of this study was to test whether EAM may help in the diagnosis of concealed cardiomyopathies in athletes with VAs and an apparently normal heart. Methods: We studied 13 consecutive competitive athletes (12 males, age 30 ± 13 years) who had documentation of VAs within the previous 6 months on 12-lead electrocardiogram (ECG), 24-hour Holter ECG, or ECG exercise testing and who were judged as having a structurally normal heart after a thorough noninvasive evaluation, including signal-averaged ECG, transthoracic echocardiogram, and cardiac magnetic resonance imaging. Depending on the presumed site of VA origin according to 12-lead ECG criteria, patients underwent right or left ventricular EAM and EAM-guided endomyocardial biopsy. Results: Presenting arrhythmias included sustained ventricular tachycardia (n = 3), multiple episodes of nonsustained ventricular tachycardia (n = 7), and frequent ventricular ectopic beats (>1,000 during 24 hours; n = 3). Three patients had a history of syncope. Twelve (92{\%}) patients had at least one low-voltage region at EAM, which corresponded at EAM-guided endomyocardial biopsy to the histological diagnosis of active myocarditis in seven patients and of arrhythmogenic right ventricular cardiomyopathy in five. In one patient the histological evidence of contraction band necrosis allowed the unmasking of caffeine and ephedrine abuse. Conclusions: Electroanatomical substrate mapping may help diagnose concealed myocardial diseases in competitive athletes presenting with recent-onset VAs and an apparently normal heart. Further studies are warranted to assess the prognostic implications of such subtle myocardial abnormalities.",
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AU - Pieroni, Maurizio

AU - Santangeli, Pasquale

AU - Bartoletti, Stefano

AU - Casella, Michela

AU - Pelargonio, Gemma

AU - Smaldone, Costantino

AU - Bianco, Massimiliano

AU - Di Biase, Luigi

AU - Bellocci, Fulvio

AU - Zeppilli, Paolo

AU - Fiorentini, Cesare

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KW - Ventricular arrhythmias

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