COMT genotype and response to cognitive remediation in schizophrenia

Jean Pierre Lindenmayer, Anzalee Khan, Herbert M. Lachman, Susan R. McGurk, Abraham Goldring, Amod Thanju, Saurabh Kaushik

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: A functional polymorphism of the catechol-. O-methyltransferase (. COMT) gene (Val158Met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity. This study evaluated the association of the COMT Val108/158 Met genotype with response to computerized neurocognitive remediation (CRT). Method: 145 subjects with DSM-IV-TR schizophrenia or schizoaffective disorder were genotyped via saliva sampling. Subjects were evaluated on neurocognitive assessments (MATRICS) and clinical symptoms (PANSS) at baseline and endpoint after 12. weeks of CRT. "Improvement" was defined as ≥. 67% of cognitive domains (≥. 4) showing performance increases. If ≤. 67% (≤. 2) of domains improved, the change was defined as "minimal improvement." A general linear model was conducted for change of each cognitive domain. Results: Of 145 subjects, data from 138 subjects were usable. Distribution of COMT genotype: Met/Met: 28 (20.29%), Val/Met: 61 (44.20%), and Val/Val: 49 (35.51%). No significant differences were seen among genotype groups at baseline or across genotype group for "Improvement" vs. "Minimal Improvement." GLM analysis showed significant differences in Verbal Learning (p= 0.003), Visual Learning (p= 0.014) and Attention/Vigilance (p= 0.011) favoring Met/Met and Val/Met groups. Conclusions: The low activity Met allele (Met/Met; Val/Met) was associated with significantly greater improvements in the MATRICS domains of Verbal Learning, Visual Learning and Attention/Vigilance after CRT.

Original languageEnglish (US)
Article number6512
Pages (from-to)279-284
Number of pages6
JournalSchizophrenia Research
Volume168
Issue number1-2
DOIs
StatePublished - Oct 1 2015

Fingerprint

Schizophrenia
Genotype
Verbal Learning
Learning
Methyltransferases
Saliva
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Linear Models
Healthy Volunteers
Alleles
Cognitive Remediation
Genes

Keywords

  • Cognitive remediation
  • COMT genotype
  • Schizophrenia
  • Social cognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Lindenmayer, J. P., Khan, A., Lachman, H. M., McGurk, S. R., Goldring, A., Thanju, A., & Kaushik, S. (2015). COMT genotype and response to cognitive remediation in schizophrenia. Schizophrenia Research, 168(1-2), 279-284. [6512]. https://doi.org/10.1016/j.schres.2015.07.037

COMT genotype and response to cognitive remediation in schizophrenia. / Lindenmayer, Jean Pierre; Khan, Anzalee; Lachman, Herbert M.; McGurk, Susan R.; Goldring, Abraham; Thanju, Amod; Kaushik, Saurabh.

In: Schizophrenia Research, Vol. 168, No. 1-2, 6512, 01.10.2015, p. 279-284.

Research output: Contribution to journalArticle

Lindenmayer, JP, Khan, A, Lachman, HM, McGurk, SR, Goldring, A, Thanju, A & Kaushik, S 2015, 'COMT genotype and response to cognitive remediation in schizophrenia', Schizophrenia Research, vol. 168, no. 1-2, 6512, pp. 279-284. https://doi.org/10.1016/j.schres.2015.07.037
Lindenmayer JP, Khan A, Lachman HM, McGurk SR, Goldring A, Thanju A et al. COMT genotype and response to cognitive remediation in schizophrenia. Schizophrenia Research. 2015 Oct 1;168(1-2):279-284. 6512. https://doi.org/10.1016/j.schres.2015.07.037
Lindenmayer, Jean Pierre ; Khan, Anzalee ; Lachman, Herbert M. ; McGurk, Susan R. ; Goldring, Abraham ; Thanju, Amod ; Kaushik, Saurabh. / COMT genotype and response to cognitive remediation in schizophrenia. In: Schizophrenia Research. 2015 ; Vol. 168, No. 1-2. pp. 279-284.
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abstract = "Background: A functional polymorphism of the catechol-. O-methyltransferase (. COMT) gene (Val158Met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity. This study evaluated the association of the COMT Val108/158 Met genotype with response to computerized neurocognitive remediation (CRT). Method: 145 subjects with DSM-IV-TR schizophrenia or schizoaffective disorder were genotyped via saliva sampling. Subjects were evaluated on neurocognitive assessments (MATRICS) and clinical symptoms (PANSS) at baseline and endpoint after 12. weeks of CRT. {"}Improvement{"} was defined as ≥. 67{\%} of cognitive domains (≥. 4) showing performance increases. If ≤. 67{\%} (≤. 2) of domains improved, the change was defined as {"}minimal improvement.{"} A general linear model was conducted for change of each cognitive domain. Results: Of 145 subjects, data from 138 subjects were usable. Distribution of COMT genotype: Met/Met: 28 (20.29{\%}), Val/Met: 61 (44.20{\%}), and Val/Val: 49 (35.51{\%}). No significant differences were seen among genotype groups at baseline or across genotype group for {"}Improvement{"} vs. {"}Minimal Improvement.{"} GLM analysis showed significant differences in Verbal Learning (p= 0.003), Visual Learning (p= 0.014) and Attention/Vigilance (p= 0.011) favoring Met/Met and Val/Met groups. Conclusions: The low activity Met allele (Met/Met; Val/Met) was associated with significantly greater improvements in the MATRICS domains of Verbal Learning, Visual Learning and Attention/Vigilance after CRT.",
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AB - Background: A functional polymorphism of the catechol-. O-methyltransferase (. COMT) gene (Val158Met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity. This study evaluated the association of the COMT Val108/158 Met genotype with response to computerized neurocognitive remediation (CRT). Method: 145 subjects with DSM-IV-TR schizophrenia or schizoaffective disorder were genotyped via saliva sampling. Subjects were evaluated on neurocognitive assessments (MATRICS) and clinical symptoms (PANSS) at baseline and endpoint after 12. weeks of CRT. "Improvement" was defined as ≥. 67% of cognitive domains (≥. 4) showing performance increases. If ≤. 67% (≤. 2) of domains improved, the change was defined as "minimal improvement." A general linear model was conducted for change of each cognitive domain. Results: Of 145 subjects, data from 138 subjects were usable. Distribution of COMT genotype: Met/Met: 28 (20.29%), Val/Met: 61 (44.20%), and Val/Val: 49 (35.51%). No significant differences were seen among genotype groups at baseline or across genotype group for "Improvement" vs. "Minimal Improvement." GLM analysis showed significant differences in Verbal Learning (p= 0.003), Visual Learning (p= 0.014) and Attention/Vigilance (p= 0.011) favoring Met/Met and Val/Met groups. Conclusions: The low activity Met allele (Met/Met; Val/Met) was associated with significantly greater improvements in the MATRICS domains of Verbal Learning, Visual Learning and Attention/Vigilance after CRT.

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