Computerized tomographic imaging of cryosurgical iceball formation in brain

Richard P. Moser, Ira Richmond Abbott, III, Clifton L. Stephens, Ya Yen Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Computerized tomography (CT) was used to monitor the exact anatomical location and dimensions of the cryosurgical iceball within the brain. The gross and microscopic appearance of the tissue iceball was examined in both acute and chronic animals. Iceball formation was monitored in the brain of four dogs under a general anesthesia. The radiographic image of the iceball was that of a well-demarcated radiolucent sphere that disappeared upon thawing. The post-thaw contrast-enhanced CT scan revealed a zone of blood-brain barrier breakdown extending no more than 1 mm beyond the maximum diameter that the iceball had attained. Histological examination demonstrated a sharp transition from frankly necrotic brain within the iceball to the normal cytoarchitecture of the surrounding neuropil. The safety and efficacy of a neurosurgical ablative procedure depends on the precision with which it can be generated. The use of CT imaging to monitor the formation of the cryosurgical iceball offers the neurosurgeon a means to precisely control the size of the ablative lesion. Small deeply situated brain tumors can be incorporated into the iceball under direct CT observation, thereby ensuring the completeness of the cryoablation while minimizing damage to the surrounding brain.

Original languageEnglish (US)
Pages (from-to)368-375
Number of pages8
JournalCryobiology
Volume24
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Computerized tomography
tomography
Brain
Tomography
image analysis
brain
Imaging techniques
Neurosurgical Procedures
Cryosurgery
Neuropil
Blood-Brain Barrier
Brain Neoplasms
Thawing
blood-brain barrier
General Anesthesia
monitoring
thawing
lesions (animal)
Observation
Dogs

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Computerized tomographic imaging of cryosurgical iceball formation in brain. / Moser, Richard P.; Abbott, III, Ira Richmond; Stephens, Clifton L.; Lee, Ya Yen.

In: Cryobiology, Vol. 24, No. 4, 1987, p. 368-375.

Research output: Contribution to journalArticle

Moser, Richard P. ; Abbott, III, Ira Richmond ; Stephens, Clifton L. ; Lee, Ya Yen. / Computerized tomographic imaging of cryosurgical iceball formation in brain. In: Cryobiology. 1987 ; Vol. 24, No. 4. pp. 368-375.
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