Computational Assessment of Protein–protein Binding Affinity by Reversely Engineering the Energetics in Protein Complexes

Mathematics

• Affine transformation 100%
• Protein 92%
• Engineering 72%
• Mutation 24%
• Protein-protein Interaction 12%
• Diabetes 10%
• First-principles 10%
• Cross-validation 9%
• Cancer 8%
• Absolute value 7%
• Predict 7%
• Pairwise 7%
• Monte Carlo Simulation 7%
• Interaction 5%
• Dependent 5%
• Model 2%

Medicine & Life Sciences

• Mutation 49%
• Protein Engineering 40%
• Weights and Measures 37%
• Protein Stability 35%
• Proteins 32%
• Datasets 23%
• Neoplasms 9%

Chemical Compounds

• Kd 67%
• Protein 36%
• Mutation 28%
• Weight 11%
• Monte Carlo Method 11%
• Molecular Recognition 11%
• Environment 6%
• Surface 3%