Abstract
Alcohol use Disorder (AUD) is one of the leading causes of morbidity and mortality worldwide. The progression of the disorder is associated with the development of compulsive alcohol use, which in turn contributes to the high relapse rate and poor longer term functioning reported in most patients, even with treatment. While the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines AUD by a cluster of symptoms, parsing its heterogeneous phenotype by domains of behavior such as compulsivity may be a critical step to improve outcomes of this condition. Still, neurobiological underpinnings of compulsivity need to be fully elucidated in AUD in order to better design targeted treatment strategies. In this manuscript, we review and discuss findings supporting common mechanisms between AUD and OCD, dissecting the construct of compulsivity and focusing specifically on characteristic disruptions in habit learning and cognitive control in the two disorders. Finally, neuromodulatory interventions are proposed as a probe to test compulsivity as key pathophysiologic feature of AUD, and as a potential therapy for the subgroup of individuals with compulsive alcohol use, i.e., the more resistant stage of the disorder. This transdiagnostic approach may help to destigmatize the disorder, and suggest potential treatment targets across different conditions.
| Original language | English (US) |
|---|---|
| Article number | 70 |
| Journal | Frontiers in Behavioral Neuroscience |
| Volume | 13 |
| DOIs | |
| State | Published - Jan 30 2019 |
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Keywords
- Alcohol use disorder
- Cognitive control
- Compulsivity
- Habit learning
- Neuromodulation
- Obsessive compulsive disorder
- Transcranial magnetic stimulation
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience
Cite this
Compulsivity in alcohol use disorder and obsessive compulsive disorder : Implications for neuromodulation. / Burchi, Elisabetta; Makris, Nikolaos; Lee, Mary; Pallanti, Stefano; Hollander, Eric.
In: Frontiers in Behavioral Neuroscience, Vol. 13, 70, 30.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Compulsivity in alcohol use disorder and obsessive compulsive disorder
T2 - Implications for neuromodulation
AU - Burchi, Elisabetta
AU - Makris, Nikolaos
AU - Lee, Mary
AU - Pallanti, Stefano
AU - Hollander, Eric
PY - 2019/1/30
Y1 - 2019/1/30
N2 - Alcohol use Disorder (AUD) is one of the leading causes of morbidity and mortality worldwide. The progression of the disorder is associated with the development of compulsive alcohol use, which in turn contributes to the high relapse rate and poor longer term functioning reported in most patients, even with treatment. While the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines AUD by a cluster of symptoms, parsing its heterogeneous phenotype by domains of behavior such as compulsivity may be a critical step to improve outcomes of this condition. Still, neurobiological underpinnings of compulsivity need to be fully elucidated in AUD in order to better design targeted treatment strategies. In this manuscript, we review and discuss findings supporting common mechanisms between AUD and OCD, dissecting the construct of compulsivity and focusing specifically on characteristic disruptions in habit learning and cognitive control in the two disorders. Finally, neuromodulatory interventions are proposed as a probe to test compulsivity as key pathophysiologic feature of AUD, and as a potential therapy for the subgroup of individuals with compulsive alcohol use, i.e., the more resistant stage of the disorder. This transdiagnostic approach may help to destigmatize the disorder, and suggest potential treatment targets across different conditions.
AB - Alcohol use Disorder (AUD) is one of the leading causes of morbidity and mortality worldwide. The progression of the disorder is associated with the development of compulsive alcohol use, which in turn contributes to the high relapse rate and poor longer term functioning reported in most patients, even with treatment. While the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines AUD by a cluster of symptoms, parsing its heterogeneous phenotype by domains of behavior such as compulsivity may be a critical step to improve outcomes of this condition. Still, neurobiological underpinnings of compulsivity need to be fully elucidated in AUD in order to better design targeted treatment strategies. In this manuscript, we review and discuss findings supporting common mechanisms between AUD and OCD, dissecting the construct of compulsivity and focusing specifically on characteristic disruptions in habit learning and cognitive control in the two disorders. Finally, neuromodulatory interventions are proposed as a probe to test compulsivity as key pathophysiologic feature of AUD, and as a potential therapy for the subgroup of individuals with compulsive alcohol use, i.e., the more resistant stage of the disorder. This transdiagnostic approach may help to destigmatize the disorder, and suggest potential treatment targets across different conditions.
KW - Alcohol use disorder
KW - Cognitive control
KW - Compulsivity
KW - Habit learning
KW - Neuromodulation
KW - Obsessive compulsive disorder
KW - Transcranial magnetic stimulation
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UR - http://www.scopus.com/inward/citedby.url?scp=85064202735&partnerID=8YFLogxK
U2 - 10.3389/fnbeh.2019.00070
DO - 10.3389/fnbeh.2019.00070
M3 - Article
VL - 13
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
SN - 1662-5153
M1 - 70
ER -