TY - JOUR
T1 - Compulsivity in alcohol use disorder and obsessive compulsive disorder
T2 - Implications for neuromodulation
AU - Burchi, Elisabetta
AU - Makris, Nikolaos
AU - Lee, Mary
AU - Pallanti, Stefano
AU - Hollander, Eric
N1 - Funding Information:
1Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, United States, 2Department of Health Sciences, University of Florence, Florence, Italy, 3Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 4Psychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 5Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States, 6Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, United States, 7Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, United States
Funding Information:
Zapata, A., Minney, V. L., and Shippenberg, T. S. (2010). Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. J. Neurosci. 30, 15457–15463. doi: 10.1523/JNEUROSCI.4072-10.2010 Zhu, X., Cortes, C. R., Mathur, K., Tomasi, D., and Momenan, R. (2017). Model-free functional connectivity and impulsivity correlates of alcohol dependence: a resting-state study. Addict. Biol. 22, 206–217. doi: 10.1111/adb.12272 Conflict of Interest Statement: EH received a research grant to study dTMS in OCD from BrainsWay.
Publisher Copyright:
© 2019 Burchi, Makris, Lee, Pallanti and Hollander.
PY - 2019/1/30
Y1 - 2019/1/30
N2 - Alcohol use Disorder (AUD) is one of the leading causes of morbidity and mortality worldwide. The progression of the disorder is associated with the development of compulsive alcohol use, which in turn contributes to the high relapse rate and poor longer term functioning reported in most patients, even with treatment. While the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines AUD by a cluster of symptoms, parsing its heterogeneous phenotype by domains of behavior such as compulsivity may be a critical step to improve outcomes of this condition. Still, neurobiological underpinnings of compulsivity need to be fully elucidated in AUD in order to better design targeted treatment strategies. In this manuscript, we review and discuss findings supporting common mechanisms between AUD and OCD, dissecting the construct of compulsivity and focusing specifically on characteristic disruptions in habit learning and cognitive control in the two disorders. Finally, neuromodulatory interventions are proposed as a probe to test compulsivity as key pathophysiologic feature of AUD, and as a potential therapy for the subgroup of individuals with compulsive alcohol use, i.e., the more resistant stage of the disorder. This transdiagnostic approach may help to destigmatize the disorder, and suggest potential treatment targets across different conditions.
AB - Alcohol use Disorder (AUD) is one of the leading causes of morbidity and mortality worldwide. The progression of the disorder is associated with the development of compulsive alcohol use, which in turn contributes to the high relapse rate and poor longer term functioning reported in most patients, even with treatment. While the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines AUD by a cluster of symptoms, parsing its heterogeneous phenotype by domains of behavior such as compulsivity may be a critical step to improve outcomes of this condition. Still, neurobiological underpinnings of compulsivity need to be fully elucidated in AUD in order to better design targeted treatment strategies. In this manuscript, we review and discuss findings supporting common mechanisms between AUD and OCD, dissecting the construct of compulsivity and focusing specifically on characteristic disruptions in habit learning and cognitive control in the two disorders. Finally, neuromodulatory interventions are proposed as a probe to test compulsivity as key pathophysiologic feature of AUD, and as a potential therapy for the subgroup of individuals with compulsive alcohol use, i.e., the more resistant stage of the disorder. This transdiagnostic approach may help to destigmatize the disorder, and suggest potential treatment targets across different conditions.
KW - Alcohol use disorder
KW - Cognitive control
KW - Compulsivity
KW - Habit learning
KW - Neuromodulation
KW - Obsessive compulsive disorder
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85064202735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064202735&partnerID=8YFLogxK
U2 - 10.3389/fnbeh.2019.00070
DO - 10.3389/fnbeh.2019.00070
M3 - Article
AN - SCOPUS:85064202735
VL - 13
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
SN - 1662-5153
M1 - 70
ER -