Comprehensive Control of Human Papillomavirus Infections and Related Diseases

F. Xavier Bosch, Thomas R. Broker, David Forman, Anna Barbara Moscicki, Maura L. Gillison, John Doorbar, Peter L. Stern, Margaret Stanley, Marc Arbyn, Mario Poljak, Jack Cuzick, Philip E. Castle, John T. Schiller, Lauri E. Markowitz, William A. Fisher, Karen Canfell, Lynette A. Denny, Eduardo L. Franco, Marc Steben, Mark A. KaneMark Schiffman, Chris J.L.M. Meijer, Rengaswamy Sankaranarayanan, Xavier Castellsagué, Jane J. Kim, Maria Brotons, Laia Alemany, Ginesa Albero, Mireia Diaz, Silvia de Sanjosé, Ahti Anttila, Lawrence Banks, Christine Bergeron, Jerome L. Belinson, Johannes Berkhof, Ignacio G. Bravo, Freddie Bray, Julia M.L. Brotherton, Laia Bruni, Ann Burchell, Anil Chaturvedi, Harrell Chesson, Myriam Chevarie-Davis, Heather Cubie, Shelley L. Deeks, Catherine de Martel, Silvia de Sanjosé, Joakim Dillner, Mark H. Einstein, Jacques Ferlay, Alison Fiander, Silvia Franceschi, Suzanne M. Garland, Anna R. Giuliano, Marc T. Goodman, Patti Gravitt, Ian N. Hampson, Isabelle Heard, Thomas Iftner, Sandra D. Isidean, Christina Jensen, Jose Jeronimo, Walter Kinney, Henry C. Kitchener, Susanne K. Kjaer, Boŝtjan J. Kocjan, George Koliopoulos, Shalini L. Kulasingam, Charles J. Lacey, D. Scott LaMontagne, Eduardo Lazcano-Ponce, Attila T. Lorincz, Joannie Lortet-Tieulent, Pontus Naucler, Gina Ogilvie, Joel Palefsky, Julian Peto, Ligia A. Pinto, Martyn Plummer, You Lin Qiao, Wim Quint, Guglielmo Ronco, Steve Schwartz, Beatriz Serrano, Jennifer Smith, Peter J.F. Snijders, Isabelle Soerjomataram, Bettie M. Steinberg, Mark Stoler, Anne Szarewski, Connie Trimble, Vivien Tsu, Pierre van Damme, Sjoerd H. van der Burg, Andrea S. Vicari, Jerome Vignat, Magnus von Knebel Doeberitz, Alex Vorsters, Susan A. Wang, Scott Wittet

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

Infection with human papillomavirus (HPV) is recognized as one of the major causes of infection-related cancer worldwide, as well as the causal factor in other diseases. Strong evidence for a causal etiology with HPV has been stated by the International Agency for Research on Cancer for cancers of the cervix uteri, penis, vulva, vagina, anus and oropharynx (including base of the tongue and tonsils). Of the estimated 12.7 million new cancers occurring in 2008 worldwide, 4.8% were attributable to HPV infection, with substantially higher incidence and mortality rates seen in developing versus developed countries. In recent years, we have gained tremendous knowledge about HPVs and their interactions with host cells, tissues and the immune system; have validated and implemented strategies for safe and efficacious prophylactic vaccination against HPV infections; have developed increasingly sensitive and specific molecular diagnostic tools for HPV detection for use in cervical cancer screening; and have substantially increased global awareness of HPV and its many associated diseases in women, men, and children. While these achievements exemplify the success of biomedical research in generating important public health interventions, they also generate new and daunting challenges: costs of HPV prevention and medical care, the implementation of what is technically possible, socio-political resistance to prevention opportunities, and the very wide ranges of national economic capabilities and health care systems. Gains and challenges faced in the quest for comprehensive control of HPV infection and HPV-related cancers and other disease are summarized in this review. The information presented may be viewed in terms of a reframed paradigm of prevention of cervical cancer and other HPV-related diseases that will include strategic combinations of at least four major components: 1) routine introduction of HPV vaccines to women in all countries, 2) extension and simplification of existing screening programs using HPV-based technology, 3) extension of adapted screening programs to developing populations, and 4) consideration of the broader spectrum of cancers and other diseases preventable by HPV vaccination in women, as well as in men. Despite the huge advances already achieved, there must be ongoing efforts including international advocacy to achieve widespread-optimally universal-implementation of HPV prevention strategies in both developed and developing countries. This article summarizes information from the chapters presented in a special ICO Monograph '. Comprehensive Control of HPV Infections and Related Diseases' Vaccine Volume 30, Supplement 5, 2012. Additional details on each subtopic and full information regarding the supporting literature references may be found in the original chapters.

Original languageEnglish (US)
Pages (from-to)11-131
Number of pages121
JournalVaccine
Volume31
Issue numberSUPPL.8
DOIs
StatePublished - Nov 22 2013

Keywords

  • Anal cancer
  • Cervical cancer
  • HPV
  • HPV testing
  • HPV vaccination
  • Oropharyngeal cancer
  • Penile cancer
  • Prevention
  • Screening
  • Vaginal cancer
  • Vulvar cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Bosch, F. X., Broker, T. R., Forman, D., Moscicki, A. B., Gillison, M. L., Doorbar, J., Stern, P. L., Stanley, M., Arbyn, M., Poljak, M., Cuzick, J., Castle, P. E., Schiller, J. T., Markowitz, L. E., Fisher, W. A., Canfell, K., Denny, L. A., Franco, E. L., Steben, M., ... Wittet, S. (2013). Comprehensive Control of Human Papillomavirus Infections and Related Diseases. Vaccine, 31(SUPPL.8), 11-131. https://doi.org/10.1016/j.vaccine.2013.07.026