Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

Sophia S. Wang, Allan Hildesheim, Xiaojiang Gao, Mark Schiffman, Rolando Herrero, M. Concepcion Bratti, Mark E. Sherman, Willard A. Barnes, Mitchell D. Greenberg, Larry McGowan, Rodrigue Mortel, Peter E. Schwartz, Richard J. Zaino, Andrew G. Glass, Robert D. Burk, Peter Karacki, Mary Carrington

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n = 365) or low-grade squamous epithelial lesions (LSILs; n = 275) or who were cytologically normal (control subjects; n = 681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.

Original languageEnglish (US)
Pages (from-to)598-605
Number of pages8
JournalJournal of Infectious Diseases
Volume186
Issue number5
DOIs
StatePublished - Sep 1 2002

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HLA Antigens
Epidemiologic Studies
Alleles
Neoplasms
Confidence Intervals
Natural Killer Cell Receptors
Papillomavirus Infections
Cervix Uteri
Uterine Cervical Neoplasms
Logistic Models
Odds Ratio
Regression Analysis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Wang, S. S., Hildesheim, A., Gao, X., Schiffman, M., Herrero, R., Bratti, M. C., ... Carrington, M. (2002). Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies. Journal of Infectious Diseases, 186(5), 598-605. https://doi.org/10.1086/342295

Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies. / Wang, Sophia S.; Hildesheim, Allan; Gao, Xiaojiang; Schiffman, Mark; Herrero, Rolando; Bratti, M. Concepcion; Sherman, Mark E.; Barnes, Willard A.; Greenberg, Mitchell D.; McGowan, Larry; Mortel, Rodrigue; Schwartz, Peter E.; Zaino, Richard J.; Glass, Andrew G.; Burk, Robert D.; Karacki, Peter; Carrington, Mary.

In: Journal of Infectious Diseases, Vol. 186, No. 5, 01.09.2002, p. 598-605.

Research output: Contribution to journalArticle

Wang, SS, Hildesheim, A, Gao, X, Schiffman, M, Herrero, R, Bratti, MC, Sherman, ME, Barnes, WA, Greenberg, MD, McGowan, L, Mortel, R, Schwartz, PE, Zaino, RJ, Glass, AG, Burk, RD, Karacki, P & Carrington, M 2002, 'Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies', Journal of Infectious Diseases, vol. 186, no. 5, pp. 598-605. https://doi.org/10.1086/342295
Wang, Sophia S. ; Hildesheim, Allan ; Gao, Xiaojiang ; Schiffman, Mark ; Herrero, Rolando ; Bratti, M. Concepcion ; Sherman, Mark E. ; Barnes, Willard A. ; Greenberg, Mitchell D. ; McGowan, Larry ; Mortel, Rodrigue ; Schwartz, Peter E. ; Zaino, Richard J. ; Glass, Andrew G. ; Burk, Robert D. ; Karacki, Peter ; Carrington, Mary. / Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 5. pp. 598-605.
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