TY - JOUR
T1 - Compounds containing cytosolic choline in the basal ganglia
T2 - A potential biological marker of true drug response to fluoxetine
AU - Sonawalla, Shamsah B.
AU - Renshaw, Perry F.
AU - Moore, Constance M.
AU - Alpert, Jonathan E.
AU - Nierenberg, Andrew A.
AU - Rosenbaum, Jerrold F.
AU - Fava, Maurizio
PY - 1999/10
Y1 - 1999/10
N2 - Objective: Studies have identified two types of antidepressant response: true drug response and placebo pattern response. This study examined the relationship between true drug response and choline-creatine ratios in the basal ganglia of depressed patients treated with fluoxetine. Method: The authors evaluated drug-free outpatients with major depression before (N=41) and after (N=15) 8 weeks of fluoxetine treatment, 20 mg/day, by using proton magnetic resonance spectroscopy. Results: There was a significant difference in the degree of change from baseline to week 8 in choline-creatine ratios between the true drug response group (N=8) and the placebo pattern response/nonresponse group (N=7); the true drug response patients had a 20% increase in choline-creatine ratios, and the placebo pattern response/nonresponse patients had a 12% decrease in choline-creatine ratios. Conclusions: These data suggest that true drug response to fluoxetine treatment in depression may be associated with an increase in choline- creatine ratios in the basal ganglia.
AB - Objective: Studies have identified two types of antidepressant response: true drug response and placebo pattern response. This study examined the relationship between true drug response and choline-creatine ratios in the basal ganglia of depressed patients treated with fluoxetine. Method: The authors evaluated drug-free outpatients with major depression before (N=41) and after (N=15) 8 weeks of fluoxetine treatment, 20 mg/day, by using proton magnetic resonance spectroscopy. Results: There was a significant difference in the degree of change from baseline to week 8 in choline-creatine ratios between the true drug response group (N=8) and the placebo pattern response/nonresponse group (N=7); the true drug response patients had a 20% increase in choline-creatine ratios, and the placebo pattern response/nonresponse patients had a 12% decrease in choline-creatine ratios. Conclusions: These data suggest that true drug response to fluoxetine treatment in depression may be associated with an increase in choline- creatine ratios in the basal ganglia.
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U2 - 10.1176/ajp.156.10.1638
DO - 10.1176/ajp.156.10.1638
M3 - Article
C2 - 10518178
AN - SCOPUS:0032819613
SN - 0002-953X
VL - 156
SP - 1638
EP - 1640
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 10
ER -