Compounds containing cytosolic choline in the basal ganglia

A potential biological marker of true drug response to fluoxetine

Shamsah B. Sonawalla, Perry F. Renshaw, Constance M. Moore, Jonathan E. Alpert, Andrew A. Nierenberg, Jerrold F. Rosenbaum, Maurizio Fava

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objective: Studies have identified two types of antidepressant response: true drug response and placebo pattern response. This study examined the relationship between true drug response and choline-creatine ratios in the basal ganglia of depressed patients treated with fluoxetine. Method: The authors evaluated drug-free outpatients with major depression before (N=41) and after (N=15) 8 weeks of fluoxetine treatment, 20 mg/day, by using proton magnetic resonance spectroscopy. Results: There was a significant difference in the degree of change from baseline to week 8 in choline-creatine ratios between the true drug response group (N=8) and the placebo pattern response/nonresponse group (N=7); the true drug response patients had a 20% increase in choline-creatine ratios, and the placebo pattern response/nonresponse patients had a 12% decrease in choline-creatine ratios. Conclusions: These data suggest that true drug response to fluoxetine treatment in depression may be associated with an increase in choline- creatine ratios in the basal ganglia.

Original languageEnglish (US)
Pages (from-to)1638-1640
Number of pages3
JournalAmerican Journal of Psychiatry
Volume156
Issue number10
StatePublished - Oct 1999
Externally publishedYes

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Fluoxetine
Choline
Basal Ganglia
Creatine
Biomarkers
Pharmaceutical Preparations
Placebos
Antidepressive Agents
Outpatients
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Sonawalla, S. B., Renshaw, P. F., Moore, C. M., Alpert, J. E., Nierenberg, A. A., Rosenbaum, J. F., & Fava, M. (1999). Compounds containing cytosolic choline in the basal ganglia: A potential biological marker of true drug response to fluoxetine. American Journal of Psychiatry, 156(10), 1638-1640.

Compounds containing cytosolic choline in the basal ganglia : A potential biological marker of true drug response to fluoxetine. / Sonawalla, Shamsah B.; Renshaw, Perry F.; Moore, Constance M.; Alpert, Jonathan E.; Nierenberg, Andrew A.; Rosenbaum, Jerrold F.; Fava, Maurizio.

In: American Journal of Psychiatry, Vol. 156, No. 10, 10.1999, p. 1638-1640.

Research output: Contribution to journalArticle

Sonawalla, SB, Renshaw, PF, Moore, CM, Alpert, JE, Nierenberg, AA, Rosenbaum, JF & Fava, M 1999, 'Compounds containing cytosolic choline in the basal ganglia: A potential biological marker of true drug response to fluoxetine', American Journal of Psychiatry, vol. 156, no. 10, pp. 1638-1640.
Sonawalla, Shamsah B. ; Renshaw, Perry F. ; Moore, Constance M. ; Alpert, Jonathan E. ; Nierenberg, Andrew A. ; Rosenbaum, Jerrold F. ; Fava, Maurizio. / Compounds containing cytosolic choline in the basal ganglia : A potential biological marker of true drug response to fluoxetine. In: American Journal of Psychiatry. 1999 ; Vol. 156, No. 10. pp. 1638-1640.
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