Complications of the ketogenic diet

Karen R. Ballaban-Gil, C. Callahan, C. O'Dell, M. Pappo, Solomon L. Moshe, Shlomo Shinnar

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Purpose: The ketogenic diet has been successfully used in treatment of pediatric epilepsy for >70 years. Few serious complications caused by the diet have been reported. We report complications that have been experienced by children receiving the ketogenic diet. Methods: In a 22-month period, we treated 52 children with the classic ketogenic diet and monitored them in a prospective manner. Results: Five children (10%) experienced serious adverse events (AE) after initiation of the diet. Four patients (80%) were treated with valproate (VPA) in addition to the diet, as compared with 25 (53%) of the other 47 children. Two patients developed severe hypoproteinemia within 4 weeks of initiation of the diet, and I of them also developed lipemia and hemolytic anemia. A third child developed Fanconi's renal tubular acidosis within 1 month of diet initiation. Two other children manifested marked increases in liver function tests, 1 during the initiation phase and the other 13 months later. Conclusions: Clinicians who wish to use the ketogenic diet must be aware of the potential of serious AE and possible interactions of the diet with VPA.

Original languageEnglish (US)
Pages (from-to)744-748
Number of pages5
JournalEpilepsia
Volume39
Issue number7
DOIs
StatePublished - Jul 1998

Fingerprint

Ketogenic Diet
Diet
Valproic Acid
Renal Tubular Acidosis
Hypoproteinemia
Liver Function Tests
Hemolytic Anemia
Hyperlipidemias
Epilepsy
Pediatrics

Keywords

  • Complications
  • Epilepsy
  • Ketogenic diet

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Complications of the ketogenic diet. / Ballaban-Gil, Karen R.; Callahan, C.; O'Dell, C.; Pappo, M.; Moshe, Solomon L.; Shinnar, Shlomo.

In: Epilepsia, Vol. 39, No. 7, 07.1998, p. 744-748.

Research output: Contribution to journalArticle

Ballaban-Gil, Karen R. ; Callahan, C. ; O'Dell, C. ; Pappo, M. ; Moshe, Solomon L. ; Shinnar, Shlomo. / Complications of the ketogenic diet. In: Epilepsia. 1998 ; Vol. 39, No. 7. pp. 744-748.
@article{2f2e136bda564c379fc7a933c5a4b9ef,
title = "Complications of the ketogenic diet",
abstract = "Purpose: The ketogenic diet has been successfully used in treatment of pediatric epilepsy for >70 years. Few serious complications caused by the diet have been reported. We report complications that have been experienced by children receiving the ketogenic diet. Methods: In a 22-month period, we treated 52 children with the classic ketogenic diet and monitored them in a prospective manner. Results: Five children (10{\%}) experienced serious adverse events (AE) after initiation of the diet. Four patients (80{\%}) were treated with valproate (VPA) in addition to the diet, as compared with 25 (53{\%}) of the other 47 children. Two patients developed severe hypoproteinemia within 4 weeks of initiation of the diet, and I of them also developed lipemia and hemolytic anemia. A third child developed Fanconi's renal tubular acidosis within 1 month of diet initiation. Two other children manifested marked increases in liver function tests, 1 during the initiation phase and the other 13 months later. Conclusions: Clinicians who wish to use the ketogenic diet must be aware of the potential of serious AE and possible interactions of the diet with VPA.",
keywords = "Complications, Epilepsy, Ketogenic diet",
author = "Ballaban-Gil, {Karen R.} and C. Callahan and C. O'Dell and M. Pappo and Moshe, {Solomon L.} and Shlomo Shinnar",
year = "1998",
month = "7",
doi = "10.1111/j.1528-1157.1998.tb01160.x",
language = "English (US)",
volume = "39",
pages = "744--748",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Complications of the ketogenic diet

AU - Ballaban-Gil, Karen R.

AU - Callahan, C.

AU - O'Dell, C.

AU - Pappo, M.

AU - Moshe, Solomon L.

AU - Shinnar, Shlomo

PY - 1998/7

Y1 - 1998/7

N2 - Purpose: The ketogenic diet has been successfully used in treatment of pediatric epilepsy for >70 years. Few serious complications caused by the diet have been reported. We report complications that have been experienced by children receiving the ketogenic diet. Methods: In a 22-month period, we treated 52 children with the classic ketogenic diet and monitored them in a prospective manner. Results: Five children (10%) experienced serious adverse events (AE) after initiation of the diet. Four patients (80%) were treated with valproate (VPA) in addition to the diet, as compared with 25 (53%) of the other 47 children. Two patients developed severe hypoproteinemia within 4 weeks of initiation of the diet, and I of them also developed lipemia and hemolytic anemia. A third child developed Fanconi's renal tubular acidosis within 1 month of diet initiation. Two other children manifested marked increases in liver function tests, 1 during the initiation phase and the other 13 months later. Conclusions: Clinicians who wish to use the ketogenic diet must be aware of the potential of serious AE and possible interactions of the diet with VPA.

AB - Purpose: The ketogenic diet has been successfully used in treatment of pediatric epilepsy for >70 years. Few serious complications caused by the diet have been reported. We report complications that have been experienced by children receiving the ketogenic diet. Methods: In a 22-month period, we treated 52 children with the classic ketogenic diet and monitored them in a prospective manner. Results: Five children (10%) experienced serious adverse events (AE) after initiation of the diet. Four patients (80%) were treated with valproate (VPA) in addition to the diet, as compared with 25 (53%) of the other 47 children. Two patients developed severe hypoproteinemia within 4 weeks of initiation of the diet, and I of them also developed lipemia and hemolytic anemia. A third child developed Fanconi's renal tubular acidosis within 1 month of diet initiation. Two other children manifested marked increases in liver function tests, 1 during the initiation phase and the other 13 months later. Conclusions: Clinicians who wish to use the ketogenic diet must be aware of the potential of serious AE and possible interactions of the diet with VPA.

KW - Complications

KW - Epilepsy

KW - Ketogenic diet

UR - http://www.scopus.com/inward/record.url?scp=0031871763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031871763&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1157.1998.tb01160.x

DO - 10.1111/j.1528-1157.1998.tb01160.x

M3 - Article

C2 - 9670903

AN - SCOPUS:0031871763

VL - 39

SP - 744

EP - 748

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 7

ER -