TY - JOUR
T1 - Complete response to thalidomide and dexamethasone in a patient with necrobiotic xanthogranuloma associated with monoclonal gammopathy
T2 - A case report and review of the literature
AU - Efebera, Yvonne
AU - Blanchard, Elizabeth
AU - Allam, Charles
AU - Han, Andrew
AU - Lee, Saem
AU - Munshi, Nikhil
PY - 2011/6
Y1 - 2011/6
N2 - Necrobiotic xanthogranuloma (NXG) was first described in 1980 by Kossard and Winkelmann in an article in which they discussed 8 patients with xanthomatous plaques who were noted to have monoclonal gammopathy, predominantly of the Ig(immunoglobulin)G-κ type. 1 Since then more than 50 patients with this disorder have been described, with approximately 80% of them having an associated monoclonal gammopathy. We describe the first case, to our knowledge, of NXG with associated monoclonal gammopathy treated with thalidomide plus dexamethasone, achieving complete resolution of the skin lesions and sustaining response more than 3 years after treatment.
AB - Necrobiotic xanthogranuloma (NXG) was first described in 1980 by Kossard and Winkelmann in an article in which they discussed 8 patients with xanthomatous plaques who were noted to have monoclonal gammopathy, predominantly of the Ig(immunoglobulin)G-κ type. 1 Since then more than 50 patients with this disorder have been described, with approximately 80% of them having an associated monoclonal gammopathy. We describe the first case, to our knowledge, of NXG with associated monoclonal gammopathy treated with thalidomide plus dexamethasone, achieving complete resolution of the skin lesions and sustaining response more than 3 years after treatment.
KW - MGUS
KW - Multiple myeloma
KW - Necrobiotic xanthogranuloma
KW - Thalidomide
UR - http://www.scopus.com/inward/record.url?scp=80053376380&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053376380&partnerID=8YFLogxK
U2 - 10.1016/j.clml.2011.03.020
DO - 10.1016/j.clml.2011.03.020
M3 - Article
C2 - 21658660
AN - SCOPUS:80053376380
SN - 2152-2650
VL - 11
SP - 298
EP - 302
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 3
ER -