Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy

David M. Loeb, D. Ashley Hill, Jeffrey S. Dome

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Congenital mesoblastic nephroma (CMN) is usually cured by surgery. The sensitivity of this tumor to chemotherapy is unknown. The recent description of a t(12;15)(p13;q25) chromosomal translocation in both cellular CMN and congenital infantile fibrosarcoma suggests that these entities have a common pathogenesis, and that cellular CMN might respond to chemotherapy like congenital infantile fibrosarcoma does. The authors describe three patients with recurrent cellular CMN who showed a complete response to chemotherapy. Based on these patients and a review of the literature, the authors suggest that chemotherapy be considered as a part of the therapy for recurrent or unresectable cellular CMN.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume24
Issue number6
DOIs
StatePublished - Aug 1 2002
Externally publishedYes

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Keywords

  • Cancer recurrence
  • Chemotherapy
  • Congenital infantile fibrosarcoma
  • Mesoblastic nephroma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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