Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development

Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike Van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun Wook Lee, Sung Hyun Park, Lung Chi Chen, Mitchell D. Cohen, Emanuela Taioli

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. New York University (NYU) and Mount Sinai have recreated WTC exposure in rodents to observe the resulting systemic and local biological responses. These experiments aid in the interpretation of epidemiological observations and are useful for understanding the carcinogenesis process in the exposed human WTC cohort. Here we describe the implementation of a tissue bank system for the rodents experimentally exposed to WTC dust. NYU samples were experimentally exposed to WTC dust via intratracheal inhalation that mimicked conditions in the immediate aftermath of the disaster. Tissue from Mount Sinai was derived from genetically modified mice exposed to WTC dust via nasal instillation. All processed tissues include annotations of the experimental design, WTC dust concentration/dose, exposure route and duration, genetic background of the rodent, and method of tissue isolation/storage. A biobank of tissue from rodents exposed to WTC dust has been compiled representing an important resource for the scientific community. The biobank remains available as a scientific resource for future research through established mechanisms for samples request and utilization. Studies using the WTC tissue bank would benefit from confirming their findings in corresponding tissues from organs of animals experimentally exposed to WTC dust. Studies on rodent tissues will advance the understanding of the biology of the tumors developed by WTC responders and ultimately impact the modalities of treatment, and the probability of success and survival of WTC cancer patients.

Original languageEnglish (US)
Article number342
JournalJournal of Translational Medicine
Volume17
Issue number1
DOIs
StatePublished - Oct 11 2019

Keywords

  • Biorepository
  • Rodents
  • World Trade Center Dust

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lieberman-Cribbin, W., Tuminello, S., Gillezeau, C., Van Gerwen, M., Brody, R., Mulholland, D. J., Horton, L., Sisco, M., Prophete, C., Zelikoff, J., Lee, H. W., Park, S. H., Chen, L. C., Cohen, M. D., & Taioli, E. (2019). Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development. Journal of Translational Medicine, 17(1), [342]. https://doi.org/10.1186/s12967-019-2089-7