TY - JOUR
T1 - Complement in neuroprotection and neurodegeneration
AU - Yanamadala, Vijay
AU - Friedlander, Robert M.
N1 - Funding Information:
This work was supported by the Paul and Daisy Soros Fellowship, the Huntington's Disease Society of America Donald A. King Fellowship and the American Medical Association Seed Grant (to V.Y.) and by National Institutes of Health–National Institute of Neurological Disorders and Stroke Grant RO1 NS051756 (R.M.F.), RO1 NS039324 (R.M.F.), the Coalition for the Cure of Huntington's disease, and CHDI.
PY - 2010/2
Y1 - 2010/2
N2 - Acute neurodegeneration is associated with high morbidity and mortality, and there are few effective treatments. Inflammation is central to the process of neuronal death, yet the roles of the complement cascade in this process have proven to be complex and hard to unravel. The complement cascade is involved in triggering cell death and recruiting cells of the immune system to sites of inflammation, including the brain. However, complement might also have important neuroprotective roles that are only now coming to light. Recent evidence suggests that targeted activation of complement might be a potential approach for treatment of stroke and other acute neurodegenerative diseases. Here, we review these novel neuroprotective roles of the complement cascade, focusing on signaling pathways that might provide new therapeutic targets in acute neuronal injury.
AB - Acute neurodegeneration is associated with high morbidity and mortality, and there are few effective treatments. Inflammation is central to the process of neuronal death, yet the roles of the complement cascade in this process have proven to be complex and hard to unravel. The complement cascade is involved in triggering cell death and recruiting cells of the immune system to sites of inflammation, including the brain. However, complement might also have important neuroprotective roles that are only now coming to light. Recent evidence suggests that targeted activation of complement might be a potential approach for treatment of stroke and other acute neurodegenerative diseases. Here, we review these novel neuroprotective roles of the complement cascade, focusing on signaling pathways that might provide new therapeutic targets in acute neuronal injury.
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U2 - 10.1016/j.molmed.2009.12.001
DO - 10.1016/j.molmed.2009.12.001
M3 - Review article
C2 - 20116331
AN - SCOPUS:76349084466
SN - 1471-4914
VL - 16
SP - 69
EP - 76
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 2
ER -