Abstract
The human major histocompatibility complex (MHC)-linked genes C2,BF,C4A,C4B occur in populations and segregate in families as single genetic units or complotypes. Analysis for significant three-point linkage disequilibrium between HLA-B, DR and complotype on normal caucasian chromosomes 6p yields about a dozen haplotypes that account for most of the known HLA-B/HLA-DR linkage disequilibrium pairs previously noted in normal caucasian populations. We refer to the HLA-B/DR/complotype sets with significant linkage disequilibrium as extended haplotypes since they often show limited variation at other MHC-linked loci. From the study of MHC haplotypes in 21-hydroxylase deficiency, C2 deficiency and type 1 diabetes, it is becoming apparent that it is extended haplotypes rather than their individual alleles that are markers for these MHC-associated diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-28 |
| Number of pages | 10 |
| Journal | Biochemical Society Symposia |
| Volume | 51 |
| State | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
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Complement genes of the major histocompatibility complex (complotypes), extended haplotypes and disease markers. / Alper, C. A.; Awdeh, Z.; Raum, Donald Douglas; Yunis, E. J.
In: Biochemical Society Symposia, Vol. 51, 1986, p. 19-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Complement genes of the major histocompatibility complex (complotypes), extended haplotypes and disease markers.
AU - Alper, C. A.
AU - Awdeh, Z.
AU - Raum, Donald Douglas
AU - Yunis, E. J.
PY - 1986
Y1 - 1986
N2 - The human major histocompatibility complex (MHC)-linked genes C2,BF,C4A,C4B occur in populations and segregate in families as single genetic units or complotypes. Analysis for significant three-point linkage disequilibrium between HLA-B, DR and complotype on normal caucasian chromosomes 6p yields about a dozen haplotypes that account for most of the known HLA-B/HLA-DR linkage disequilibrium pairs previously noted in normal caucasian populations. We refer to the HLA-B/DR/complotype sets with significant linkage disequilibrium as extended haplotypes since they often show limited variation at other MHC-linked loci. From the study of MHC haplotypes in 21-hydroxylase deficiency, C2 deficiency and type 1 diabetes, it is becoming apparent that it is extended haplotypes rather than their individual alleles that are markers for these MHC-associated diseases.
AB - The human major histocompatibility complex (MHC)-linked genes C2,BF,C4A,C4B occur in populations and segregate in families as single genetic units or complotypes. Analysis for significant three-point linkage disequilibrium between HLA-B, DR and complotype on normal caucasian chromosomes 6p yields about a dozen haplotypes that account for most of the known HLA-B/HLA-DR linkage disequilibrium pairs previously noted in normal caucasian populations. We refer to the HLA-B/DR/complotype sets with significant linkage disequilibrium as extended haplotypes since they often show limited variation at other MHC-linked loci. From the study of MHC haplotypes in 21-hydroxylase deficiency, C2 deficiency and type 1 diabetes, it is becoming apparent that it is extended haplotypes rather than their individual alleles that are markers for these MHC-associated diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022849830&partnerID=8YFLogxK
M3 - Article
C2 - 3493006
AN - SCOPUS:0022849830
VL - 51
SP - 19
EP - 28
JO - Biochemical Society Symposium
JF - Biochemical Society Symposium
SN - 0067-8694
ER -