Compensatory hypertrophy and failure in gradual pressure-overloaded guinea pig heart

F. M. Siri, Charles W. Nordin, S. M. Factor, E. Sonnenblick, R. Aronson

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Left ventricular hypertrophy has been produced in the guinea pig by a procedure that gradually increases left ventricular afterload. A mildly constricting band was placed around the ascending aortas of very young guinea pigs (225-275 g). With growth to 500-1,000 g, left ventricular systolic pressure increased and left ventricular hypertrophy developed. In ~ 50% of these animals, the hypertrophy was associated with normal left ventricular function and with no unusual symptoms or evidence of heart failure. The other animals developed dyspnea, which appeared an average of 41 days after banding. Dyspneic animals had normal body weight, markedly increased right ventricular and lung weights, decreased left ventricular norepinephrine content, diminished maximum left ventricular pressure generating capacity, and a significantly higher incidence of left ventricular interstitial and perivascular fibrosis. These findings demonstrate that even when left ventricular overload is imposed gradually by banding the aortas of young animals, myocardial decompensation ultimately ensues in a significant proportion of such animals. The slow imposition of loading, the slow rate of decompensation, and the ability to identify animals in heart failure by clinical dyspnea make this model uniquely valuable for studies on the mechanisms of heart failure.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume257
Issue number3
StatePublished - 1989

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Hypertrophy
Guinea Pigs
Pressure
Heart Failure
Left Ventricular Hypertrophy
Ventricular Pressure
Dyspnea
Aorta
Ideal Body Weight
Left Ventricular Function
Norepinephrine
Fibrosis
Blood Pressure
Weights and Measures
Lung
Incidence
Growth

ASJC Scopus subject areas

  • Physiology

Cite this

Compensatory hypertrophy and failure in gradual pressure-overloaded guinea pig heart. / Siri, F. M.; Nordin, Charles W.; Factor, S. M.; Sonnenblick, E.; Aronson, R.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 257, No. 3, 1989.

Research output: Contribution to journalArticle

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