Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues

Zeqi Huang, Michael J. Fasco, Simon D. Spivack, Laurence S. Kaminsky

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

Original languageEnglish (US)
Pages (from-to)2589-2592
Number of pages4
JournalCancer Research
Volume57
Issue number13
StatePublished - Jul 1 1997
Externally publishedYes

Fingerprint

Cytochrome P-450 CYP2D6
Lung
Messenger RNA
Neoplasms
Pseudogenes
Cytochrome P-450 Enzyme System
Genes
Carcinogenesis
Breast

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues. / Huang, Zeqi; Fasco, Michael J.; Spivack, Simon D.; Kaminsky, Laurence S.

In: Cancer Research, Vol. 57, No. 13, 01.07.1997, p. 2589-2592.

Research output: Contribution to journalArticle

Huang, Zeqi ; Fasco, Michael J. ; Spivack, Simon D. ; Kaminsky, Laurence S. / Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues. In: Cancer Research. 1997 ; Vol. 57, No. 13. pp. 2589-2592.
@article{930f3a38c91043239c805ffbf77b04bb,
title = "Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues",
abstract = "Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.",
author = "Zeqi Huang and Fasco, {Michael J.} and Spivack, {Simon D.} and Kaminsky, {Laurence S.}",
year = "1997",
month = "7",
day = "1",
language = "English (US)",
volume = "57",
pages = "2589--2592",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "13",

}

TY - JOUR

T1 - Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues

AU - Huang, Zeqi

AU - Fasco, Michael J.

AU - Spivack, Simon D.

AU - Kaminsky, Laurence S.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

AB - Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

UR - http://www.scopus.com/inward/record.url?scp=0030789095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030789095&partnerID=8YFLogxK

M3 - Article

VL - 57

SP - 2589

EP - 2592

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 13

ER -