Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues

Zeqi Huang, Michael J. Fasco, Simon Spivack, Laurence S. Kaminsky

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

Original languageEnglish (US)
Pages (from-to)2589-2592
Number of pages4
JournalCancer Research
Volume57
Issue number13
Publication statusPublished - Jul 1 1997
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this