Comparison of renal response parameters for juvenile membranous plus proliferative lupus nephritis versus isolated proliferative lupus nephritis

A cross-sectional analysis of the CARRA Registry

A. Boneparth, Norman Todd Ilowite

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Lupus nephritis (LN) affects many patients with juvenile systemic lupus erythematosus (SLE) and is a significant cause of disease morbidity. Membranous plus proliferative LN (M + PLN) may represent a more difficult to treat subtype of juvenile LN, compared to isolated proliferative LN (PLN). In this retrospective observational study, we utilized data from the Childhood Arthritis and Rheumatism Research Alliance (CARRA) registry to compare response rates for pediatric M + PLN versus PLN. Response was assessed at the most recent CARRA registry visit gathered ≥6 months after diagnostic kidney biopsy. Estimated glomerular filtration rate (GFR) less than 90 ml/min/1.73 m2, indicating renal insufficiency, was found in 16.1% of patients with M + PLN and 6.1% of patients with PLN (P = 0.071). We found no significant difference in achievement of response in either hematuria or proteinuria between PLN and M + PLN groups or between subgroups determined by presence of class III vs. class IV proliferative disease. Exposure rates to mycophenolate, cyclophosphamide, and rituximab were similar between groups. Future studies will be necessary to correlate pediatric LN renal histology data with treatment response as well as other disease outcome measures.

Original languageEnglish (US)
Pages (from-to)898-904
Number of pages7
JournalLupus
Volume23
Issue number9
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Lupus Nephritis
Rheumatic Diseases
Arthritis
Registries
Cross-Sectional Studies
Kidney
Research
Pediatrics
Hematuria
Glomerular Filtration Rate
Proteinuria
Systemic Lupus Erythematosus
Cyclophosphamide
Observational Studies
Renal Insufficiency
Histology
Retrospective Studies
Outcome Assessment (Health Care)
Morbidity
Biopsy

Keywords

  • CARRA registry
  • Lupus
  • membranous
  • nephritis
  • pediatric
  • proliferative
  • response

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{d4f099b7db88427b966141155e233981,
title = "Comparison of renal response parameters for juvenile membranous plus proliferative lupus nephritis versus isolated proliferative lupus nephritis: A cross-sectional analysis of the CARRA Registry",
abstract = "Lupus nephritis (LN) affects many patients with juvenile systemic lupus erythematosus (SLE) and is a significant cause of disease morbidity. Membranous plus proliferative LN (M + PLN) may represent a more difficult to treat subtype of juvenile LN, compared to isolated proliferative LN (PLN). In this retrospective observational study, we utilized data from the Childhood Arthritis and Rheumatism Research Alliance (CARRA) registry to compare response rates for pediatric M + PLN versus PLN. Response was assessed at the most recent CARRA registry visit gathered ≥6 months after diagnostic kidney biopsy. Estimated glomerular filtration rate (GFR) less than 90 ml/min/1.73 m2, indicating renal insufficiency, was found in 16.1{\%} of patients with M + PLN and 6.1{\%} of patients with PLN (P = 0.071). We found no significant difference in achievement of response in either hematuria or proteinuria between PLN and M + PLN groups or between subgroups determined by presence of class III vs. class IV proliferative disease. Exposure rates to mycophenolate, cyclophosphamide, and rituximab were similar between groups. Future studies will be necessary to correlate pediatric LN renal histology data with treatment response as well as other disease outcome measures.",
keywords = "CARRA registry, Lupus, membranous, nephritis, pediatric, proliferative, response",
author = "A. Boneparth and Ilowite, {Norman Todd}",
year = "2014",
doi = "10.1177/0961203314531841",
language = "English (US)",
volume = "23",
pages = "898--904",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "9",

}

TY - JOUR

T1 - Comparison of renal response parameters for juvenile membranous plus proliferative lupus nephritis versus isolated proliferative lupus nephritis

T2 - A cross-sectional analysis of the CARRA Registry

AU - Boneparth, A.

AU - Ilowite, Norman Todd

PY - 2014

Y1 - 2014

N2 - Lupus nephritis (LN) affects many patients with juvenile systemic lupus erythematosus (SLE) and is a significant cause of disease morbidity. Membranous plus proliferative LN (M + PLN) may represent a more difficult to treat subtype of juvenile LN, compared to isolated proliferative LN (PLN). In this retrospective observational study, we utilized data from the Childhood Arthritis and Rheumatism Research Alliance (CARRA) registry to compare response rates for pediatric M + PLN versus PLN. Response was assessed at the most recent CARRA registry visit gathered ≥6 months after diagnostic kidney biopsy. Estimated glomerular filtration rate (GFR) less than 90 ml/min/1.73 m2, indicating renal insufficiency, was found in 16.1% of patients with M + PLN and 6.1% of patients with PLN (P = 0.071). We found no significant difference in achievement of response in either hematuria or proteinuria between PLN and M + PLN groups or between subgroups determined by presence of class III vs. class IV proliferative disease. Exposure rates to mycophenolate, cyclophosphamide, and rituximab were similar between groups. Future studies will be necessary to correlate pediatric LN renal histology data with treatment response as well as other disease outcome measures.

AB - Lupus nephritis (LN) affects many patients with juvenile systemic lupus erythematosus (SLE) and is a significant cause of disease morbidity. Membranous plus proliferative LN (M + PLN) may represent a more difficult to treat subtype of juvenile LN, compared to isolated proliferative LN (PLN). In this retrospective observational study, we utilized data from the Childhood Arthritis and Rheumatism Research Alliance (CARRA) registry to compare response rates for pediatric M + PLN versus PLN. Response was assessed at the most recent CARRA registry visit gathered ≥6 months after diagnostic kidney biopsy. Estimated glomerular filtration rate (GFR) less than 90 ml/min/1.73 m2, indicating renal insufficiency, was found in 16.1% of patients with M + PLN and 6.1% of patients with PLN (P = 0.071). We found no significant difference in achievement of response in either hematuria or proteinuria between PLN and M + PLN groups or between subgroups determined by presence of class III vs. class IV proliferative disease. Exposure rates to mycophenolate, cyclophosphamide, and rituximab were similar between groups. Future studies will be necessary to correlate pediatric LN renal histology data with treatment response as well as other disease outcome measures.

KW - CARRA registry

KW - Lupus

KW - membranous

KW - nephritis

KW - pediatric

KW - proliferative

KW - response

UR - http://www.scopus.com/inward/record.url?scp=84903751664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903751664&partnerID=8YFLogxK

U2 - 10.1177/0961203314531841

DO - 10.1177/0961203314531841

M3 - Article

VL - 23

SP - 898

EP - 904

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 9

ER -