Comparison of preparative transplantation regimens using carmustine/etoposide/cisplatin or busulfan/etoposide/cyclophosphamide in lymphoid malignancies

P. Crilley, H. Lazarus, D. Topolsky, N. Ciobanu, R. J. Creger, R. M. Fox, S. I. Bulova, D. C. Shina, R. Gucalp, B. W. Cooper, W. Soegiarso, M. Styler, I. Brodsky

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Abstract

Most bone marrow transplantation preparative regimens use total body irradiation as one component. Recently, however, two non-total body irradiation containing autologous bone marrow transplantation preparative regimens have been evaluated in patients with lymphoid malignancies. The first regimen consisted of carmustine, etoposide, and cisplatin; some patients also received involved-field radiotherapy to sites of prior disease. Of the 79 patients with relapsed or refractory lymphoma who participated in this study, 57 (72%) achieved a complete remission and 40 (51%) remain in complete remission. Treatment-related deaths occurred in five patients (6%). The second preparative regimen evaluated consisted of busulfan, etoposide, and cyclophosphamide and included 21 patients with Hodgkin's lymphoma, non- Hodgkin's lymphoma, or acute lymphocytic leukemia. Sixteen patients (76%) achieved complete remission and 12 (57%) remain disease free. The regimen- related mortality rate in this study was 14%. The three treatment-related deaths were all due to pulmonary toxicity. The results of these clinical trials indicate that both the carmustine/etoposide/cisplatin regimen and the busulfan/etoposide/cyclophosphamide regimen are effective in treating lymphoid malignancies. Treatment-related toxicities and deaths are significant, but not prohibitive. Accordingly, these new preparative regimens deserve further evaluation in the treatment of patients with lymphoma or leukemia.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalSeminars in oncology
Volume20
Issue number4 SUPPL. 4
Publication statusPublished - Jan 1 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Crilley, P., Lazarus, H., Topolsky, D., Ciobanu, N., Creger, R. J., Fox, R. M., ... Brodsky, I. (1993). Comparison of preparative transplantation regimens using carmustine/etoposide/cisplatin or busulfan/etoposide/cyclophosphamide in lymphoid malignancies. Seminars in oncology, 20(4 SUPPL. 4), 50-54.