Abstract
Unrelated bone marrow transplantation (BMT) is often complicated by fatal opportunistic infections. To evaluate features unique to immune reconstitution after unrelated BMT, the lymphoid phenotype, in vitro function, and life-threatening opportunistic infections after unrelated and related T-cell-depleted (TCD) BMT were analyzed longitudinally and compared. The effects of posttransplant donor leukocyte infusions to treat or prevent cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections on immune reconstitution were also analyzed. This study demonstrates that adult recipients of TCD unrelated BMTs experience prolonged and profound deficiencies of CD3+, CD4+, and CD8+ T-cell populations when compared with pediatric recipients of unrelated BMT and adults after related BMT (P < .01), that these adults have a significantly increased risk of life-threatening opportunistic infections, and that the rate of recovery of CD4 T cells correlates with the risk of developing these infections. Recovery of normal numbers of CD3+, CD8+, and CD4+ T-cell populations is similar in children after related or unrelated BMT. This study also demonstrates that adoptive immunotherapy with small numbers of unirradiated donor leukocytes can be associated with rapid restoration of CD3+, CD4+, and CD8+ T-cell numbers, antigen-specific T-cell responses, and resolution of CMV- and EBV-associated disease after unrelated TCD BMT.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 467-480 |
| Number of pages | 14 |
| Journal | Blood |
| Volume | 93 |
| Issue number | 2 |
| State | Published - Jan 15 1999 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology
Cite this
Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation : Effect of patient age and donor leukocyte infusions. / Small, T. N.; Papadopoulos, E. B.; Boulad, F.; Black, P.; Castro-Malaspina, H.; Childs, B. H.; Collins, N.; Gillio, A.; George, D.; Jakubowski, A.; Heller, G.; Fazzari, M.; Kernan, N.; MacKinnon, S.; Szabolcs, P.; Young, J. W.; O'Reilly, R. J.
In: Blood, Vol. 93, No. 2, 15.01.1999, p. 467-480.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation
T2 - Effect of patient age and donor leukocyte infusions
AU - Small, T. N.
AU - Papadopoulos, E. B.
AU - Boulad, F.
AU - Black, P.
AU - Castro-Malaspina, H.
AU - Childs, B. H.
AU - Collins, N.
AU - Gillio, A.
AU - George, D.
AU - Jakubowski, A.
AU - Heller, G.
AU - Fazzari, M.
AU - Kernan, N.
AU - MacKinnon, S.
AU - Szabolcs, P.
AU - Young, J. W.
AU - O'Reilly, R. J.
PY - 1999/1/15
Y1 - 1999/1/15
N2 - Unrelated bone marrow transplantation (BMT) is often complicated by fatal opportunistic infections. To evaluate features unique to immune reconstitution after unrelated BMT, the lymphoid phenotype, in vitro function, and life-threatening opportunistic infections after unrelated and related T-cell-depleted (TCD) BMT were analyzed longitudinally and compared. The effects of posttransplant donor leukocyte infusions to treat or prevent cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections on immune reconstitution were also analyzed. This study demonstrates that adult recipients of TCD unrelated BMTs experience prolonged and profound deficiencies of CD3+, CD4+, and CD8+ T-cell populations when compared with pediatric recipients of unrelated BMT and adults after related BMT (P < .01), that these adults have a significantly increased risk of life-threatening opportunistic infections, and that the rate of recovery of CD4 T cells correlates with the risk of developing these infections. Recovery of normal numbers of CD3+, CD8+, and CD4+ T-cell populations is similar in children after related or unrelated BMT. This study also demonstrates that adoptive immunotherapy with small numbers of unirradiated donor leukocytes can be associated with rapid restoration of CD3+, CD4+, and CD8+ T-cell numbers, antigen-specific T-cell responses, and resolution of CMV- and EBV-associated disease after unrelated TCD BMT.
AB - Unrelated bone marrow transplantation (BMT) is often complicated by fatal opportunistic infections. To evaluate features unique to immune reconstitution after unrelated BMT, the lymphoid phenotype, in vitro function, and life-threatening opportunistic infections after unrelated and related T-cell-depleted (TCD) BMT were analyzed longitudinally and compared. The effects of posttransplant donor leukocyte infusions to treat or prevent cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections on immune reconstitution were also analyzed. This study demonstrates that adult recipients of TCD unrelated BMTs experience prolonged and profound deficiencies of CD3+, CD4+, and CD8+ T-cell populations when compared with pediatric recipients of unrelated BMT and adults after related BMT (P < .01), that these adults have a significantly increased risk of life-threatening opportunistic infections, and that the rate of recovery of CD4 T cells correlates with the risk of developing these infections. Recovery of normal numbers of CD3+, CD8+, and CD4+ T-cell populations is similar in children after related or unrelated BMT. This study also demonstrates that adoptive immunotherapy with small numbers of unirradiated donor leukocytes can be associated with rapid restoration of CD3+, CD4+, and CD8+ T-cell numbers, antigen-specific T-cell responses, and resolution of CMV- and EBV-associated disease after unrelated TCD BMT.
UR - http://www.scopus.com/inward/record.url?scp=0033555440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033555440&partnerID=8YFLogxK
M3 - Article
C2 - 9885208
AN - SCOPUS:0033555440
VL - 93
SP - 467
EP - 480
JO - Blood
JF - Blood
SN - 0006-4971
IS - 2
ER -