Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions

T. N. Small, E. B. Papadopoulos, F. Boulad, P. Black, H. Castro-Malaspina, B. H. Childs, N. Collins, A. Gillio, D. George, A. Jakubowski, G. Heller, M. Fazzari, N. Kernan, S. MacKinnon, P. Szabolcs, J. W. Young, R. J. O'Reilly

Research output: Contribution to journalArticle

365 Citations (Scopus)

Abstract

Unrelated bone marrow transplantation (BMT) is often complicated by fatal opportunistic infections. To evaluate features unique to immune reconstitution after unrelated BMT, the lymphoid phenotype, in vitro function, and life-threatening opportunistic infections after unrelated and related T-cell-depleted (TCD) BMT were analyzed longitudinally and compared. The effects of posttransplant donor leukocyte infusions to treat or prevent cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections on immune reconstitution were also analyzed. This study demonstrates that adult recipients of TCD unrelated BMTs experience prolonged and profound deficiencies of CD3+, CD4+, and CD8+ T-cell populations when compared with pediatric recipients of unrelated BMT and adults after related BMT (P < .01), that these adults have a significantly increased risk of life-threatening opportunistic infections, and that the rate of recovery of CD4 T cells correlates with the risk of developing these infections. Recovery of normal numbers of CD3+, CD8+, and CD4+ T-cell populations is similar in children after related or unrelated BMT. This study also demonstrates that adoptive immunotherapy with small numbers of unirradiated donor leukocytes can be associated with rapid restoration of CD3+, CD4+, and CD8+ T-cell numbers, antigen-specific T-cell responses, and resolution of CMV- and EBV-associated disease after unrelated TCD BMT.

Original languageEnglish (US)
Pages (from-to)467-480
Number of pages14
JournalBlood
Volume93
Issue number2
StatePublished - Jan 15 1999
Externally publishedYes

Fingerprint

T-cells
Bone Marrow Transplantation
Bone
Leukocytes
Tissue Donors
T-Lymphocytes
Opportunistic Infections
Cytomegalovirus
Viruses
Adoptive Immunotherapy
Recovery
Pediatrics
Epstein-Barr Virus Infections
Virus Diseases
Human Herpesvirus 4
Population
Restoration
Cell Count
Phenotype
Antigens

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Small, T. N., Papadopoulos, E. B., Boulad, F., Black, P., Castro-Malaspina, H., Childs, B. H., ... O'Reilly, R. J. (1999). Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions. Blood, 93(2), 467-480.

Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation : Effect of patient age and donor leukocyte infusions. / Small, T. N.; Papadopoulos, E. B.; Boulad, F.; Black, P.; Castro-Malaspina, H.; Childs, B. H.; Collins, N.; Gillio, A.; George, D.; Jakubowski, A.; Heller, G.; Fazzari, M.; Kernan, N.; MacKinnon, S.; Szabolcs, P.; Young, J. W.; O'Reilly, R. J.

In: Blood, Vol. 93, No. 2, 15.01.1999, p. 467-480.

Research output: Contribution to journalArticle

Small, TN, Papadopoulos, EB, Boulad, F, Black, P, Castro-Malaspina, H, Childs, BH, Collins, N, Gillio, A, George, D, Jakubowski, A, Heller, G, Fazzari, M, Kernan, N, MacKinnon, S, Szabolcs, P, Young, JW & O'Reilly, RJ 1999, 'Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions', Blood, vol. 93, no. 2, pp. 467-480.
Small TN, Papadopoulos EB, Boulad F, Black P, Castro-Malaspina H, Childs BH et al. Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions. Blood. 1999 Jan 15;93(2):467-480.
Small, T. N. ; Papadopoulos, E. B. ; Boulad, F. ; Black, P. ; Castro-Malaspina, H. ; Childs, B. H. ; Collins, N. ; Gillio, A. ; George, D. ; Jakubowski, A. ; Heller, G. ; Fazzari, M. ; Kernan, N. ; MacKinnon, S. ; Szabolcs, P. ; Young, J. W. ; O'Reilly, R. J. / Comparison of immune reconstitution after unrelated and related T-cell- depleted bone marrow transplantation : Effect of patient age and donor leukocyte infusions. In: Blood. 1999 ; Vol. 93, No. 2. pp. 467-480.
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