Comparison of echocardiography with technetium 99m-gated single photon emission computed tomography as diagnostic tools for left ventricular ejection fraction

Salvatore A. Chiaramida, Paturu Prasad, Nagaraju L. Choragudi, Anita M. Prakash, Ying Sun, Richard J. Lucariello

Research output: Contribution to journalArticle

18 Scopus citations


Left ventricular ejection fractions (LVEF) are routinely measured and result in critical decision-making algorithms in cardiology. This study was conducted to compare the accepted standard two-dimensional (2-D) echocardiogram ejection fraction (EFECHO) with single photon emission computed tomography rest ejection fraction (EFSPECT). Data were acquired and analyzed from 51 inpatients. EFECHO was obtained using modified Simpson's rule in the four-chamber apical view, and gated EFSPECT was computed by an automated method (Siemens ICON software). Comparison between EFECHO and EFSPECT was done by linear regression, Bland-Altman, and receiver operator characteristic (ROC) analyses. Linear regression analysis revealed EFSPECT = 1.12 × EFECHO - 3.6%, r = 0.93, n = 51, P < 0.0001. Bland-Altman analysis showed that the limits of 95% confidence for the difference between EFSPECT and EFECHO were - 12% to 18%. Ninety-eight percent of the datapoints were within the limits of confidence. The ROC analysis showed that the sensitivity and specificity for detecting abnormal EF (≤ 50%) were 85% and 86% with EFSPECT, and 91% and 90% with EFECHO. This study showed good correlation as well as agreement between SPECT and two-dimensional echocardiograms in measuring EF.

Original languageEnglish (US)
Pages (from-to)627-632
Number of pages6
Issue number8
Publication statusPublished - Jan 1 2001
Externally publishedYes



  • Bland-Altman analysis
  • Echocardiography
  • Ejection fraction
  • Modified simpson's rule
  • Receiver operating characteristic
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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