Comparison of depth of necrosis achieved by CO2- and N2O-cryotherapy

J. Mariategui, C. Santos, L. Taxa, J. Jeronimo, P. E. Castle

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: To compare the depth of necrosis achieved using CO2- and N2O-cryotherapy. Method: We treated 20 women with CO2-cryotherapy and 20 with N2O-cryotherapy 24 h prior to undergoing total hysterectomy for reasons unrelated to cervical cancer. Depth of necrosis in the ectocervix was measured on surgically removed tissue. Results: The mean depth of necrosis for the anterior lip achieved by N2O-cryotherapy was 5.3 mm compared with 3.4 mm by CO2-cryotherapy (P < 0.001). We found similar results for the posterior lip (5.0 vs 3.1 mm; P < 0.001). N2O-cryotherapy was more likely than CO2-cryotherapy to achieve a depth of necrosis of ≥ 4.8 mm for the anterior lip (75% vs 15%; P < 0.001) and posterior lip (60% vs 5%; P < 0.001). Conclusions: Our study showed that CO2-cryotherapy may not achieve the depth of necrosis necessary to completely destroy cervical precancer and therefore may be less robust than N2O-cryotherapy.

Original languageEnglish (US)
Pages (from-to)24-26
Number of pages3
JournalInternational Journal of Gynecology and Obstetrics
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • CO-cryotherapy
  • Cervical cancer
  • Cervical intraepithelial neoplasia grade 3 (CIN3)
  • Cervical precancer
  • NO-cryotherapy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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