Comparison of 2-year outcomes between zotarolimus-eluting and everolimus-eluting new-generation cobalt-chromium alloy stents in real-world diabetic patients

Tadashi Miyazaki, Azeem Latib, Vasileios F. Panoulas, Sakiko Miyazaki, Charis Costopoulos, Katsumasa Sato, Toru Naganuma, Hiroyoshi Kawamoto, Hiroyuki Daida, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: To date, it remains unknown whether different types of new-generation drug-eluting stents have a differential impact on long-term outcomes in diabetic patients. Methods and Results: In this historical cohort study (two Italian centers), we analyzed 400 diabetic patients with 553 coronary lesions treated with new-generation CoCr zotarolimus-eluting stents (R-ZES: 136 patients, 196 lesions) or everolimus-eluting stents (EES: 264 patients, 357 lesions) between October 2006 and August 2012. Primary endpoint was the occurrence of major adverse cardiac events (MACE) over a 2-year follow-up period. MACE was defined as all-cause mortality, any myocardial infarction (MI) and/or target lesion revascularization (TLR). Multivessel revascularization, intervention for restenotic lesion and use of intravascular ultrasound were significantly higher in the R-ZES group, whereas small stent (≤2.5 mm) deployment was significantly higher in the EES group. At 2-year follow-up, there was no significant difference in occurrence of MACE (R-ZES vs EES: 22.8% vs 18.9%, P=0.39). Similarly, no significant differences were observed in the composite endpoint of all-cause mortality/MI (10.0% vs 10.3%, P=0.86) or TLR (12.4% vs 7.4%, P=0.11). Adjustment for confounders and baseline propensity-score matching did not alter the aforementioned associations. Conclusion: After 2 years of follow up similar outcomes (MACE, all-cause mortality/MI, TLR) were observed in real-world diabetic patients, including those with complex lesions and patient characteristics, treated with R-ZES and EES.

Original languageEnglish (US)
Pages (from-to)E11-E18
JournalCatheterization and Cardiovascular Interventions
Volume86
Issue number1
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Keywords

  • diabetes mellitus
  • drug eluting stents (DES)
  • percutaneous coronary intervention (PES)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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