TY - JOUR
T1 - Comparing cardiopulmonary exercise testing in severe COPD patients with and without pulmonary hypertension
AU - Thirapatarapong, Wilawan
AU - Armstrong, Hilary F.
AU - Bartels, Matthew N.
N1 - Funding Information:
This work had no conflict of interest and was supported by VIDDA foundation.
Publisher Copyright:
© 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ).
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Purpose: To determine (i) the effect of PH on exercise capacity, gas exchange and oxygen pulse; (ii) the variables that correlate with mean pulmonary artery pressure (mPAP) in severe COPD patients. Methods: We reviewed 98 severe COPD patients who had pulmonary function, right heart catheterisation, and cardiopulmonary exercise testing (CPET) performed within six months of each other. PH was defined by a resting mPAP > 25. mmHg. COPD patients with and without PH were compared using the independent samples t-test and Mann-Whitney U test. Pearson correlation coefficients were used to assess the relationship between continuous variables. Results: PH was present in 32% of patients and the majority of PH was mild (mPAP, 25-35. mmHg). Peak workload, oxygen uptake and oxygen pulse on CPET were significantly lower in the PH group. Mean PAP was found to inversely correlate with peak oxygen uptake, with a tendency towards lower six-minute walk distance. No difference between two groups was seen in any of the gas exchange variables. Conclusion: In severe COPD, there is a relatively high percentage of PH which causes a decrease in exercise capacity and oxygen pulse without significantly altered ventilation as measured by CPET. Lower than expected exercise performance without a change in pulmonary function may indicate a need for evaluation for possible PH.
AB - Purpose: To determine (i) the effect of PH on exercise capacity, gas exchange and oxygen pulse; (ii) the variables that correlate with mean pulmonary artery pressure (mPAP) in severe COPD patients. Methods: We reviewed 98 severe COPD patients who had pulmonary function, right heart catheterisation, and cardiopulmonary exercise testing (CPET) performed within six months of each other. PH was defined by a resting mPAP > 25. mmHg. COPD patients with and without PH were compared using the independent samples t-test and Mann-Whitney U test. Pearson correlation coefficients were used to assess the relationship between continuous variables. Results: PH was present in 32% of patients and the majority of PH was mild (mPAP, 25-35. mmHg). Peak workload, oxygen uptake and oxygen pulse on CPET were significantly lower in the PH group. Mean PAP was found to inversely correlate with peak oxygen uptake, with a tendency towards lower six-minute walk distance. No difference between two groups was seen in any of the gas exchange variables. Conclusion: In severe COPD, there is a relatively high percentage of PH which causes a decrease in exercise capacity and oxygen pulse without significantly altered ventilation as measured by CPET. Lower than expected exercise performance without a change in pulmonary function may indicate a need for evaluation for possible PH.
KW - COPD
KW - Cardiopulmonary exercise testing
KW - Exercise capacity
KW - Gas exchange
KW - Pulmonary hypertension
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U2 - 10.1016/j.hlc.2013.12.015
DO - 10.1016/j.hlc.2013.12.015
M3 - Article
C2 - 24793962
AN - SCOPUS:84923646672
VL - 23
SP - 833
EP - 840
JO - Heart Lung and Circulation
JF - Heart Lung and Circulation
SN - 1443-9506
IS - 9
ER -