Abstract
Purpose: To determine (i) the effect of PH on exercise capacity, gas exchange and oxygen pulse; (ii) the variables that correlate with mean pulmonary artery pressure (mPAP) in severe COPD patients. Methods: We reviewed 98 severe COPD patients who had pulmonary function, right heart catheterisation, and cardiopulmonary exercise testing (CPET) performed within six months of each other. PH was defined by a resting mPAP > 25. mmHg. COPD patients with and without PH were compared using the independent samples t-test and Mann-Whitney U test. Pearson correlation coefficients were used to assess the relationship between continuous variables. Results: PH was present in 32% of patients and the majority of PH was mild (mPAP, 25-35. mmHg). Peak workload, oxygen uptake and oxygen pulse on CPET were significantly lower in the PH group. Mean PAP was found to inversely correlate with peak oxygen uptake, with a tendency towards lower six-minute walk distance. No difference between two groups was seen in any of the gas exchange variables. Conclusion: In severe COPD, there is a relatively high percentage of PH which causes a decrease in exercise capacity and oxygen pulse without significantly altered ventilation as measured by CPET. Lower than expected exercise performance without a change in pulmonary function may indicate a need for evaluation for possible PH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 833-840 |
| Number of pages | 8 |
| Journal | Heart Lung and Circulation |
| Volume | 23 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2014 |
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Keywords
- Cardiopulmonary exercise testing
- COPD
- Exercise capacity
- Gas exchange
- Pulmonary hypertension
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pulmonary and Respiratory Medicine
- Medicine(all)
Cite this
Comparing cardiopulmonary exercise testing in severe COPD patients with and without pulmonary hypertension. / Thirapatarapong, Wilawan; Armstrong, Hilary F.; Bartels, Matthew N.
In: Heart Lung and Circulation, Vol. 23, No. 9, 01.09.2014, p. 833-840.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparing cardiopulmonary exercise testing in severe COPD patients with and without pulmonary hypertension
AU - Thirapatarapong, Wilawan
AU - Armstrong, Hilary F.
AU - Bartels, Matthew N.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Purpose: To determine (i) the effect of PH on exercise capacity, gas exchange and oxygen pulse; (ii) the variables that correlate with mean pulmonary artery pressure (mPAP) in severe COPD patients. Methods: We reviewed 98 severe COPD patients who had pulmonary function, right heart catheterisation, and cardiopulmonary exercise testing (CPET) performed within six months of each other. PH was defined by a resting mPAP > 25. mmHg. COPD patients with and without PH were compared using the independent samples t-test and Mann-Whitney U test. Pearson correlation coefficients were used to assess the relationship between continuous variables. Results: PH was present in 32% of patients and the majority of PH was mild (mPAP, 25-35. mmHg). Peak workload, oxygen uptake and oxygen pulse on CPET were significantly lower in the PH group. Mean PAP was found to inversely correlate with peak oxygen uptake, with a tendency towards lower six-minute walk distance. No difference between two groups was seen in any of the gas exchange variables. Conclusion: In severe COPD, there is a relatively high percentage of PH which causes a decrease in exercise capacity and oxygen pulse without significantly altered ventilation as measured by CPET. Lower than expected exercise performance without a change in pulmonary function may indicate a need for evaluation for possible PH.
AB - Purpose: To determine (i) the effect of PH on exercise capacity, gas exchange and oxygen pulse; (ii) the variables that correlate with mean pulmonary artery pressure (mPAP) in severe COPD patients. Methods: We reviewed 98 severe COPD patients who had pulmonary function, right heart catheterisation, and cardiopulmonary exercise testing (CPET) performed within six months of each other. PH was defined by a resting mPAP > 25. mmHg. COPD patients with and without PH were compared using the independent samples t-test and Mann-Whitney U test. Pearson correlation coefficients were used to assess the relationship between continuous variables. Results: PH was present in 32% of patients and the majority of PH was mild (mPAP, 25-35. mmHg). Peak workload, oxygen uptake and oxygen pulse on CPET were significantly lower in the PH group. Mean PAP was found to inversely correlate with peak oxygen uptake, with a tendency towards lower six-minute walk distance. No difference between two groups was seen in any of the gas exchange variables. Conclusion: In severe COPD, there is a relatively high percentage of PH which causes a decrease in exercise capacity and oxygen pulse without significantly altered ventilation as measured by CPET. Lower than expected exercise performance without a change in pulmonary function may indicate a need for evaluation for possible PH.
KW - Cardiopulmonary exercise testing
KW - COPD
KW - Exercise capacity
KW - Gas exchange
KW - Pulmonary hypertension
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UR - http://www.scopus.com/inward/citedby.url?scp=84923646672&partnerID=8YFLogxK
U2 - 10.1016/j.hlc.2013.12.015
DO - 10.1016/j.hlc.2013.12.015
M3 - Article
C2 - 24793962
AN - SCOPUS:84923646672
VL - 23
SP - 833
EP - 840
JO - Heart Lung and Circulation
JF - Heart Lung and Circulation
SN - 1443-9506
IS - 9
ER -