Comparative study on the expression of stress-response protein (srp) 72, srp 27, αB-crystallin and ubiquitin in brain tumours. An immunohistochemical investigation

S. Kato, A. Hirano, M. Kato, F. Herz, E. Ohama

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

This immunohistochemical study compares the expression of stress-response (heat-shock) protein (srp) 72, srp 27, αB-crystallin and ubiquitin in 86 primary human brain tumours and 21 carcinoma metastases to the central nervous system. Normal brain tissues were included for control purposes. Serial sections of formalin-fixed, paraffin-embedded tissues were used. Most meningiomas (17/23), glioblastomas (11/12) and breast carcinoma metastases (9/10) and some astrocytomas (7/13), pituitary tumours (4/9) and lung cancer metastases (5/11) had tumour cells that reacted with one or more of the antibodies used. Around 43% of the meningiomas and 25% of the glioblastomas expressed srp 72 only. Sole expression of srp 27, αB-crystallin or ubiquitin was seen in several tumours. Some meningiomas (3/23) and breast cancer metastases (4/10) co-expressed srp 72 and srp 27, and 1/3 of the glioblastomas co-expressed srp27 and αB-crystallin. We conclude that primary and metastatic tumours of the brain produce stress-related proteins and that certain tumours concurrently express two or more srp's.

Original languageEnglish (US)
Pages (from-to)436-442
Number of pages7
JournalNeuropathology and Applied Neurobiology
Volume19
Issue number5
StatePublished - 1993

Fingerprint

Crystallins
Ubiquitin
Heat-Shock Proteins
Brain Neoplasms
Meningioma
Glioblastoma
Neoplasm Metastasis
Neoplasms
IgA receptor
Astrocytoma
Pituitary Neoplasms
Paraffin
Formaldehyde
Lung Neoplasms
Central Nervous System
Breast Neoplasms
Carcinoma
Antibodies
Brain

Keywords

  • αβ-crystallin
  • Brain tumours
  • Heat-shock proteins
  • Stress response protein 72
  • Stress-response protein 27
  • Ubiquitin

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Comparative study on the expression of stress-response protein (srp) 72, srp 27, αB-crystallin and ubiquitin in brain tumours. An immunohistochemical investigation. / Kato, S.; Hirano, A.; Kato, M.; Herz, F.; Ohama, E.

In: Neuropathology and Applied Neurobiology, Vol. 19, No. 5, 1993, p. 436-442.

Research output: Contribution to journalArticle

@article{63893dca29ce47d4bc163aa95be1b964,
title = "Comparative study on the expression of stress-response protein (srp) 72, srp 27, αB-crystallin and ubiquitin in brain tumours. An immunohistochemical investigation",
abstract = "This immunohistochemical study compares the expression of stress-response (heat-shock) protein (srp) 72, srp 27, αB-crystallin and ubiquitin in 86 primary human brain tumours and 21 carcinoma metastases to the central nervous system. Normal brain tissues were included for control purposes. Serial sections of formalin-fixed, paraffin-embedded tissues were used. Most meningiomas (17/23), glioblastomas (11/12) and breast carcinoma metastases (9/10) and some astrocytomas (7/13), pituitary tumours (4/9) and lung cancer metastases (5/11) had tumour cells that reacted with one or more of the antibodies used. Around 43{\%} of the meningiomas and 25{\%} of the glioblastomas expressed srp 72 only. Sole expression of srp 27, αB-crystallin or ubiquitin was seen in several tumours. Some meningiomas (3/23) and breast cancer metastases (4/10) co-expressed srp 72 and srp 27, and 1/3 of the glioblastomas co-expressed srp27 and αB-crystallin. We conclude that primary and metastatic tumours of the brain produce stress-related proteins and that certain tumours concurrently express two or more srp's.",
keywords = "αβ-crystallin, Brain tumours, Heat-shock proteins, Stress response protein 72, Stress-response protein 27, Ubiquitin",
author = "S. Kato and A. Hirano and M. Kato and F. Herz and E. Ohama",
year = "1993",
language = "English (US)",
volume = "19",
pages = "436--442",
journal = "Neuropathology and Applied Neurobiology",
issn = "0305-1846",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Comparative study on the expression of stress-response protein (srp) 72, srp 27, αB-crystallin and ubiquitin in brain tumours. An immunohistochemical investigation

AU - Kato, S.

AU - Hirano, A.

AU - Kato, M.

AU - Herz, F.

AU - Ohama, E.

PY - 1993

Y1 - 1993

N2 - This immunohistochemical study compares the expression of stress-response (heat-shock) protein (srp) 72, srp 27, αB-crystallin and ubiquitin in 86 primary human brain tumours and 21 carcinoma metastases to the central nervous system. Normal brain tissues were included for control purposes. Serial sections of formalin-fixed, paraffin-embedded tissues were used. Most meningiomas (17/23), glioblastomas (11/12) and breast carcinoma metastases (9/10) and some astrocytomas (7/13), pituitary tumours (4/9) and lung cancer metastases (5/11) had tumour cells that reacted with one or more of the antibodies used. Around 43% of the meningiomas and 25% of the glioblastomas expressed srp 72 only. Sole expression of srp 27, αB-crystallin or ubiquitin was seen in several tumours. Some meningiomas (3/23) and breast cancer metastases (4/10) co-expressed srp 72 and srp 27, and 1/3 of the glioblastomas co-expressed srp27 and αB-crystallin. We conclude that primary and metastatic tumours of the brain produce stress-related proteins and that certain tumours concurrently express two or more srp's.

AB - This immunohistochemical study compares the expression of stress-response (heat-shock) protein (srp) 72, srp 27, αB-crystallin and ubiquitin in 86 primary human brain tumours and 21 carcinoma metastases to the central nervous system. Normal brain tissues were included for control purposes. Serial sections of formalin-fixed, paraffin-embedded tissues were used. Most meningiomas (17/23), glioblastomas (11/12) and breast carcinoma metastases (9/10) and some astrocytomas (7/13), pituitary tumours (4/9) and lung cancer metastases (5/11) had tumour cells that reacted with one or more of the antibodies used. Around 43% of the meningiomas and 25% of the glioblastomas expressed srp 72 only. Sole expression of srp 27, αB-crystallin or ubiquitin was seen in several tumours. Some meningiomas (3/23) and breast cancer metastases (4/10) co-expressed srp 72 and srp 27, and 1/3 of the glioblastomas co-expressed srp27 and αB-crystallin. We conclude that primary and metastatic tumours of the brain produce stress-related proteins and that certain tumours concurrently express two or more srp's.

KW - αβ-crystallin

KW - Brain tumours

KW - Heat-shock proteins

KW - Stress response protein 72

KW - Stress-response protein 27

KW - Ubiquitin

UR - http://www.scopus.com/inward/record.url?scp=0027484092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027484092&partnerID=8YFLogxK

M3 - Article

C2 - 8278027

AN - SCOPUS:0027484092

VL - 19

SP - 436

EP - 442

JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

SN - 0305-1846

IS - 5

ER -