Comparative study of spinal cord ubiquitin expression in post-poliomyelitis and sporadic amyotrophic lateral sclerosis

Hidefumi Ito, Asao Hirano

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study addresses the suggested possible pathogenetic relationship between the late-onset muscular atrophy in patients with the prior diagnosis of poliomyelitis and amyotrophic lateral sclerosis (ALS). For this purpose we applied immunohistochemical techniques to determine the presence of pathological structures that were stained for ubiquitin (a protein involved in degenerative processes) in the spinal cords of patients with a history of poliomyelitis and compared the results with those of ALS, a condition in which cytoplasmic ubiquitin-positive inclusions are invariably found in the anterior horn cells. Our results indicate that post-poliomyelitis patients have no ubiquitinreactive inclusion bodies in these cells; however, some immunopositive globular and cord-shaped structures are seen in less-affected areas. Similar structures were also found in the spinal cords from patients with ALS and from normal individuals. Our findings would suggest that the pathogenesis of late muscular atrophy in post-poliomyelitis patients is dissimilar to that of ALS.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalActa Neuropathologica
Volume87
Issue number4
DOIs
StatePublished - Apr 1994

Fingerprint

Poliomyelitis
Ubiquitin
Amyotrophic Lateral Sclerosis
Spinal Cord
Postpoliomyelitis Syndrome
Anterior Horn Cells
Muscular Atrophy
Inclusion Bodies
Amyotrophic lateral sclerosis 1
Proteins

Keywords

  • Amyotrophic lateral sclerosis
  • Filamentous inclusion
  • Post-poliomyelitis
  • Spinal cord
  • Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Comparative study of spinal cord ubiquitin expression in post-poliomyelitis and sporadic amyotrophic lateral sclerosis. / Ito, Hidefumi; Hirano, Asao.

In: Acta Neuropathologica, Vol. 87, No. 4, 04.1994, p. 425-429.

Research output: Contribution to journalArticle

@article{4040ed05adff467b88f0b3cd69a2e4f1,
title = "Comparative study of spinal cord ubiquitin expression in post-poliomyelitis and sporadic amyotrophic lateral sclerosis",
abstract = "This study addresses the suggested possible pathogenetic relationship between the late-onset muscular atrophy in patients with the prior diagnosis of poliomyelitis and amyotrophic lateral sclerosis (ALS). For this purpose we applied immunohistochemical techniques to determine the presence of pathological structures that were stained for ubiquitin (a protein involved in degenerative processes) in the spinal cords of patients with a history of poliomyelitis and compared the results with those of ALS, a condition in which cytoplasmic ubiquitin-positive inclusions are invariably found in the anterior horn cells. Our results indicate that post-poliomyelitis patients have no ubiquitinreactive inclusion bodies in these cells; however, some immunopositive globular and cord-shaped structures are seen in less-affected areas. Similar structures were also found in the spinal cords from patients with ALS and from normal individuals. Our findings would suggest that the pathogenesis of late muscular atrophy in post-poliomyelitis patients is dissimilar to that of ALS.",
keywords = "Amyotrophic lateral sclerosis, Filamentous inclusion, Post-poliomyelitis, Spinal cord, Ubiquitin",
author = "Hidefumi Ito and Asao Hirano",
year = "1994",
month = "4",
doi = "10.1007/BF00313613",
language = "English (US)",
volume = "87",
pages = "425--429",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Comparative study of spinal cord ubiquitin expression in post-poliomyelitis and sporadic amyotrophic lateral sclerosis

AU - Ito, Hidefumi

AU - Hirano, Asao

PY - 1994/4

Y1 - 1994/4

N2 - This study addresses the suggested possible pathogenetic relationship between the late-onset muscular atrophy in patients with the prior diagnosis of poliomyelitis and amyotrophic lateral sclerosis (ALS). For this purpose we applied immunohistochemical techniques to determine the presence of pathological structures that were stained for ubiquitin (a protein involved in degenerative processes) in the spinal cords of patients with a history of poliomyelitis and compared the results with those of ALS, a condition in which cytoplasmic ubiquitin-positive inclusions are invariably found in the anterior horn cells. Our results indicate that post-poliomyelitis patients have no ubiquitinreactive inclusion bodies in these cells; however, some immunopositive globular and cord-shaped structures are seen in less-affected areas. Similar structures were also found in the spinal cords from patients with ALS and from normal individuals. Our findings would suggest that the pathogenesis of late muscular atrophy in post-poliomyelitis patients is dissimilar to that of ALS.

AB - This study addresses the suggested possible pathogenetic relationship between the late-onset muscular atrophy in patients with the prior diagnosis of poliomyelitis and amyotrophic lateral sclerosis (ALS). For this purpose we applied immunohistochemical techniques to determine the presence of pathological structures that were stained for ubiquitin (a protein involved in degenerative processes) in the spinal cords of patients with a history of poliomyelitis and compared the results with those of ALS, a condition in which cytoplasmic ubiquitin-positive inclusions are invariably found in the anterior horn cells. Our results indicate that post-poliomyelitis patients have no ubiquitinreactive inclusion bodies in these cells; however, some immunopositive globular and cord-shaped structures are seen in less-affected areas. Similar structures were also found in the spinal cords from patients with ALS and from normal individuals. Our findings would suggest that the pathogenesis of late muscular atrophy in post-poliomyelitis patients is dissimilar to that of ALS.

KW - Amyotrophic lateral sclerosis

KW - Filamentous inclusion

KW - Post-poliomyelitis

KW - Spinal cord

KW - Ubiquitin

UR - http://www.scopus.com/inward/record.url?scp=0028343837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028343837&partnerID=8YFLogxK

U2 - 10.1007/BF00313613

DO - 10.1007/BF00313613

M3 - Article

VL - 87

SP - 425

EP - 429

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 4

ER -