Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia

Rasim Gucalp, Paul Ritch, Peter H. Wiernik, P. Ravi Sarma, Alan Keller, Stephen P. Richman, Kurt Tauer, James Neidhart, Lawrence E. Mallette, Robert Siegel, Christine J. VandePol

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132 Scopus citations

Abstract

Purpose: This multicenter, double-blind, randomized trial was performed to determine the efficacy and safety of pamidronate disodium (APD) in comparison to etidronate disodium (EHDP) in the treatment of Cancer-related hypercalcemie. Patients and Methods: Sixty-five male and female adult patients with Cancer and corrected calcium levels of ≥ 12.0 mg/dL after 24 hours of hydration were randomized to receive either 60 mg APD given as a single 24-hour infusion or 7.5 mg/kg EHDP given as a 2-hour infusion daily for 3 days. Results: APD normalized corrected calcium levels in 70% (21 of 30) of patients, whereas EHDP did so in 41% (14 of 34) of patients (P = .026). The mean corrected serum calcium level decreased from 14.6 to 10.5 mg/dL in the APD-treerted group and from 13.8 to 11.6 mg/dL in the EHDP-treated group within the first week of treatment. There was no difference in response to APD in patients without versus those with bone metastases (78% v 67%). Both drugs were well tolerated. Conclusion: This study demonstrated that a single 60-mg infusion of APD is safe and more effective than EHDP given at the dose of 7.5 mg/kg for 3 days in the treatment of Cancer-related hypercalcemia.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalJournal of Clinical Oncology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Gucalp, R., Ritch, P., Wiernik, P. H., Ravi Sarma, P., Keller, A., Richman, S. P., Tauer, K., Neidhart, J., Mallette, L. E., Siegel, R., & VandePol, C. J. (1992). Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia. Journal of Clinical Oncology, 10(1), 134-142. https://doi.org/10.1200/JCO.1992.10.1.134