Comparative renal effects of midazolam and thiopental in humans

Philip W. Lebowitz, M. E. Cote, A. L. Daniels, J. V. Bonventre

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Midazolam is a water-soluble benzodiazepine whose quick onset after intravenous injection, short duration of action, absence of venous irritation, and mild cardiovascular and respiratory effects suggest its use for induction of anesthesia. The renal effects of midazolam-N2O-O2 anesthesia, as determined by renal clearance of injected insulin and para-aminohippuric acid (PAH), in hydrated ASA Class I-II surgical patients (N = 8) were compared in a double-blind fashion with a similar group of patients (N = 9) anesthetized with thiopental-N2O-O2. Except for glomerular filtration rate, there were no significant changes in any of the measured variables (blood pressure, effective renal plasma flow, renal blood flow, and renal vascular resistance). The per cent reduction in glomerular filtration rate in patients given thiopental differed significantly from that in patients given midazolam. This study suggests that midazolam, as opposed to thiopental, offers minimal advantage in maintaining renal performance at least during the period of anesthetic administration.

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalAnesthesiology
Volume59
Issue number5
StatePublished - 1983
Externally publishedYes

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Thiopental
Midazolam
Kidney
Glomerular Filtration Rate
Anesthesia
Effective Renal Plasma Flow
p-Aminohippuric Acid
Renal Circulation
Benzodiazepines
Intravenous Injections
Vascular Resistance
Anesthetics
Insulin
Blood Pressure
Water

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Lebowitz, P. W., Cote, M. E., Daniels, A. L., & Bonventre, J. V. (1983). Comparative renal effects of midazolam and thiopental in humans. Anesthesiology, 59(5), 381-384.

Comparative renal effects of midazolam and thiopental in humans. / Lebowitz, Philip W.; Cote, M. E.; Daniels, A. L.; Bonventre, J. V.

In: Anesthesiology, Vol. 59, No. 5, 1983, p. 381-384.

Research output: Contribution to journalArticle

Lebowitz, PW, Cote, ME, Daniels, AL & Bonventre, JV 1983, 'Comparative renal effects of midazolam and thiopental in humans', Anesthesiology, vol. 59, no. 5, pp. 381-384.
Lebowitz PW, Cote ME, Daniels AL, Bonventre JV. Comparative renal effects of midazolam and thiopental in humans. Anesthesiology. 1983;59(5):381-384.
Lebowitz, Philip W. ; Cote, M. E. ; Daniels, A. L. ; Bonventre, J. V. / Comparative renal effects of midazolam and thiopental in humans. In: Anesthesiology. 1983 ; Vol. 59, No. 5. pp. 381-384.
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