Comparative protein structure modelling

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

A prerequisite to understand cell functioning on the system level is the knowledge of three-dimensional protein structures that mediate biochemical interactions. The explosion in the number of available gene sequences set the stage for the next step in genome scale projects, to obtain three dimensional structures for each protein. To achieve this ambitious goal, the costly and slow structure determination experiments are boosted with theoretical approaches. The current state and recent advances in structure modelling approaches are reviewed here, with special emphasis on comparative structure modelling techniques.

Original languageEnglish (US)
Title of host publicationFrom Protein Structure to Function with Bioinformatics
Subtitle of host publicationSecond Edition
PublisherSpringer Netherlands
Pages91-134
Number of pages44
ISBN (Electronic)9789402410693
ISBN (Print)9789402410679
DOIs
StatePublished - Apr 6 2017

Keywords

  • Comparative protein structure modelling
  • Homology modelling
  • Loop modelling
  • Template-based modelling

ASJC Scopus subject areas

  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)
  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)
  • Social Sciences(all)

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