Abstract
A prerequisite to understand cell functioning on the system level is the knowledge of three-dimensional protein structures that mediate biochemical inter actions. The explosion in the number of available gene sequences set the stage for the next step in genome scale projects, to obtain three dimensional structures for each protein. To achieve this ambitious goal, the costly and slow structure determi nation experiments are boosted with theoretical approaches. The current state and recent advances in structure modelling approaches are reviewed here, with special emphasis on comparative structure modelling techniques
| Original language | English (US) |
|---|---|
| Title of host publication | From Protein Structure to Function with Bioinformatics |
| Publisher | Springer Netherlands |
| Pages | 57-90 |
| Number of pages | 34 |
| ISBN (Print) | 9781402090578 |
| DOIs | |
| State | Published - 2009 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Comparative protein structure modelling. / Fiser, Andras.
From Protein Structure to Function with Bioinformatics. Springer Netherlands, 2009. p. 57-90.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Comparative protein structure modelling
AU - Fiser, Andras
PY - 2009
Y1 - 2009
N2 - A prerequisite to understand cell functioning on the system level is the knowledge of three-dimensional protein structures that mediate biochemical inter actions. The explosion in the number of available gene sequences set the stage for the next step in genome scale projects, to obtain three dimensional structures for each protein. To achieve this ambitious goal, the costly and slow structure determi nation experiments are boosted with theoretical approaches. The current state and recent advances in structure modelling approaches are reviewed here, with special emphasis on comparative structure modelling techniques
AB - A prerequisite to understand cell functioning on the system level is the knowledge of three-dimensional protein structures that mediate biochemical inter actions. The explosion in the number of available gene sequences set the stage for the next step in genome scale projects, to obtain three dimensional structures for each protein. To achieve this ambitious goal, the costly and slow structure determi nation experiments are boosted with theoretical approaches. The current state and recent advances in structure modelling approaches are reviewed here, with special emphasis on comparative structure modelling techniques
UR - http://www.scopus.com/inward/record.url?scp=84900267861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900267861&partnerID=8YFLogxK
U2 - 10.1007/978-1-4020-9058-5_3
DO - 10.1007/978-1-4020-9058-5_3
M3 - Chapter
SN - 9781402090578
SP - 57
EP - 90
BT - From Protein Structure to Function with Bioinformatics
PB - Springer Netherlands
ER -