Comparative outcomes for patients who do and do not undergo percutaneous coronary intervention for stable coronary artery disease in new york

Edward L. Hannan, Zaza Samadashvili, Kimberly Cozzens, Gary Walford, Alice K. Jacobs, David R. Holmes, Nicholas J. Stamato, Jeffrey P. Gold, Samin Sharma, Ferdinand J. Venditti, Patricia (Tia) Powell, Spencer B. King

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

BACKGROUND-: Little is known about what treatments patients receive after being diagnosed with stable coronary artery disease or what the comparative outcomes are for routine medical treatment (RMT) versus percutaneous coronary intervention (PCI) with RMT for patients in a setting apart from randomized controlled trials. METHODS AND RESULTS-: Patients with stable coronary artery disease undergoing cardiac catheterization in New York State between 2003 and 2008 were followed up to determine the treatment they received. Patients receiving RMT and patients receiving PCI with RMT were propensity matched through the use of 20 factors that could have a bearing on outcomes. The resulting cohort of 933 matched pairs was used to compare mortality/myocardial infarction (MI), mortality, MI, and subsequent revascularization rates. A total of 89% of all patients underwent PCI with RMT. PCI/RMT patients had significantly lower adverse outcome rates at 4 years for mortality/MI (16.5% versus 21.2%; P=0.003), mortality (10.2% versus 14.5%; P=0.02), MI (8.0% versus 11.3%; P=0.007), and subsequent revascularization (24.1% versus 29.1%; P=0.005). Adjusted RMT versus (PCI with RMT) hazard ratios were 1.49 (95% confidence interval, 1.16-1.93) for mortality/MI and 1.46 (95% confidence interval, 1.08-1.97) for mortality. There were no differences for patients ≤65 years of age or for patients with single-vessel disease. CONCLUSIONS-: Most patients with stable coronary artery disease in New York undergoing catheterization between 2003 and 2008 received PCI. Patients who received PCI experienced lower mortality, mortality/MI, and revascularization rates. The reasons for this finding need to be better understood, including the possible role of low medication adherence rates that have been found in other studies.

Original languageEnglish (US)
Pages (from-to)1870-1879
Number of pages10
JournalCirculation
Volume125
Issue number15
DOIs
StatePublished - Apr 17 2012

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Percutaneous Coronary Intervention
Coronary Artery Disease
Mortality
Myocardial Infarction
Therapeutics
Confidence Intervals
Myocardial Revascularization
Medication Adherence
Cardiac Catheterization
Catheterization
Randomized Controlled Trials

Keywords

  • comparative effectiveness research
  • coronary angioplasty
  • coronary artery disease
  • medicine

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Hannan, E. L., Samadashvili, Z., Cozzens, K., Walford, G., Jacobs, A. K., Holmes, D. R., ... King, S. B. (2012). Comparative outcomes for patients who do and do not undergo percutaneous coronary intervention for stable coronary artery disease in new york. Circulation, 125(15), 1870-1879. https://doi.org/10.1161/CIRCULATIONAHA.111.071811

Comparative outcomes for patients who do and do not undergo percutaneous coronary intervention for stable coronary artery disease in new york. / Hannan, Edward L.; Samadashvili, Zaza; Cozzens, Kimberly; Walford, Gary; Jacobs, Alice K.; Holmes, David R.; Stamato, Nicholas J.; Gold, Jeffrey P.; Sharma, Samin; Venditti, Ferdinand J.; Powell, Patricia (Tia); King, Spencer B.

In: Circulation, Vol. 125, No. 15, 17.04.2012, p. 1870-1879.

Research output: Contribution to journalArticle

Hannan, EL, Samadashvili, Z, Cozzens, K, Walford, G, Jacobs, AK, Holmes, DR, Stamato, NJ, Gold, JP, Sharma, S, Venditti, FJ, Powell, PT & King, SB 2012, 'Comparative outcomes for patients who do and do not undergo percutaneous coronary intervention for stable coronary artery disease in new york', Circulation, vol. 125, no. 15, pp. 1870-1879. https://doi.org/10.1161/CIRCULATIONAHA.111.071811
Hannan, Edward L. ; Samadashvili, Zaza ; Cozzens, Kimberly ; Walford, Gary ; Jacobs, Alice K. ; Holmes, David R. ; Stamato, Nicholas J. ; Gold, Jeffrey P. ; Sharma, Samin ; Venditti, Ferdinand J. ; Powell, Patricia (Tia) ; King, Spencer B. / Comparative outcomes for patients who do and do not undergo percutaneous coronary intervention for stable coronary artery disease in new york. In: Circulation. 2012 ; Vol. 125, No. 15. pp. 1870-1879.
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abstract = "BACKGROUND-: Little is known about what treatments patients receive after being diagnosed with stable coronary artery disease or what the comparative outcomes are for routine medical treatment (RMT) versus percutaneous coronary intervention (PCI) with RMT for patients in a setting apart from randomized controlled trials. METHODS AND RESULTS-: Patients with stable coronary artery disease undergoing cardiac catheterization in New York State between 2003 and 2008 were followed up to determine the treatment they received. Patients receiving RMT and patients receiving PCI with RMT were propensity matched through the use of 20 factors that could have a bearing on outcomes. The resulting cohort of 933 matched pairs was used to compare mortality/myocardial infarction (MI), mortality, MI, and subsequent revascularization rates. A total of 89{\%} of all patients underwent PCI with RMT. PCI/RMT patients had significantly lower adverse outcome rates at 4 years for mortality/MI (16.5{\%} versus 21.2{\%}; P=0.003), mortality (10.2{\%} versus 14.5{\%}; P=0.02), MI (8.0{\%} versus 11.3{\%}; P=0.007), and subsequent revascularization (24.1{\%} versus 29.1{\%}; P=0.005). Adjusted RMT versus (PCI with RMT) hazard ratios were 1.49 (95{\%} confidence interval, 1.16-1.93) for mortality/MI and 1.46 (95{\%} confidence interval, 1.08-1.97) for mortality. There were no differences for patients ≤65 years of age or for patients with single-vessel disease. CONCLUSIONS-: Most patients with stable coronary artery disease in New York undergoing catheterization between 2003 and 2008 received PCI. Patients who received PCI experienced lower mortality, mortality/MI, and revascularization rates. The reasons for this finding need to be better understood, including the possible role of low medication adherence rates that have been found in other studies.",
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AU - Jacobs, Alice K.

AU - Holmes, David R.

AU - Stamato, Nicholas J.

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N2 - BACKGROUND-: Little is known about what treatments patients receive after being diagnosed with stable coronary artery disease or what the comparative outcomes are for routine medical treatment (RMT) versus percutaneous coronary intervention (PCI) with RMT for patients in a setting apart from randomized controlled trials. METHODS AND RESULTS-: Patients with stable coronary artery disease undergoing cardiac catheterization in New York State between 2003 and 2008 were followed up to determine the treatment they received. Patients receiving RMT and patients receiving PCI with RMT were propensity matched through the use of 20 factors that could have a bearing on outcomes. The resulting cohort of 933 matched pairs was used to compare mortality/myocardial infarction (MI), mortality, MI, and subsequent revascularization rates. A total of 89% of all patients underwent PCI with RMT. PCI/RMT patients had significantly lower adverse outcome rates at 4 years for mortality/MI (16.5% versus 21.2%; P=0.003), mortality (10.2% versus 14.5%; P=0.02), MI (8.0% versus 11.3%; P=0.007), and subsequent revascularization (24.1% versus 29.1%; P=0.005). Adjusted RMT versus (PCI with RMT) hazard ratios were 1.49 (95% confidence interval, 1.16-1.93) for mortality/MI and 1.46 (95% confidence interval, 1.08-1.97) for mortality. There were no differences for patients ≤65 years of age or for patients with single-vessel disease. CONCLUSIONS-: Most patients with stable coronary artery disease in New York undergoing catheterization between 2003 and 2008 received PCI. Patients who received PCI experienced lower mortality, mortality/MI, and revascularization rates. The reasons for this finding need to be better understood, including the possible role of low medication adherence rates that have been found in other studies.

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