Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe synaptojanin and SHIP2

Medicine & Life Sciences

• Inositol Polyphosphate 5-Phosphatases 100%
• synaptojanin 94%
• Schizosaccharomyces 75%
• Substrate Specificity 70%
• inositol-1,4,5,6-tetrakisphosphate 35%
• phosphatidylinositol 3,5-diphosphate 31%
• inositol-1,3,4,5-tetrakisphosphate 29%
• Phosphatidylinositols 28%
• Inositol Phosphates 22%
• inositol-1,2,4,5-tetrakisphosphate 20%
• inositol 2,4,5-trisphosphate 17%
• inositol 4,5-bisphosphate 17%
• inositol 1,4-bis(phosphate) 16%
• Phosphates 15%
• Phosphatidylinositol 4,5-Diphosphate 13%
• phosphatidylinositol 3,4,5-triphosphate 13%
• src Homology Domains 10%
• Catalysis 10%
• Synaptic Vesicles 10%
• Enzymes 9%
• Metals 7%
• Signal Transduction 7%
• Kinetics 6%
• Insulin 6%
• Pharmacology 5%
• Water 5%
• Lipids 5%

Chemical Compounds

• Inositol 74%
• Polyphosphate 72%
• Ins(1,4,5)P3 65%
• Inositol Phosphate 58%
• Phosphatidylinositol 25%
• Insulin Derivative 21%
• Recycling 18%
• Ionization 16%
• Water Soluble 16%
• Transition Element 15%
• Bioactivity 15%
• Lipid 14%
• Compound Isomer 14%
• Phosphate 13%
• Catalysis 13%
• Crystal Structure 10%