Comparative gene expression analysis of the fmnl family of formins during zebrafish development and implications for tissue specific functions

Adrián Santos-Ledo, Andreas Jenny, Florence L. Marlow

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Fmlns belong to the Formin family, catalysts of linear actin polymerization with mostly unknown roles in vivo. In cell culture Fmnls are involved in cell migration and adhesion and the formation of different types of protrusions including filopodia and blebs, suggesting important roles during development. Moreover, Fmnls can act downstream of Rac and Cdc42, mediators of cytoskeletal changes as targets of important pathways required for shaping tissues. The zebrafish genome encodes five Fmnls. Here we report their tissue specific expression patterns during early development and pharyngula stages. The fmnls show overlapping and distinct expression patterns, which suggest that they could regulate similar processes during development, but may also have independent functions. In particular, we find a strong maternal contribution of all fmnls, but distinct expression patterns in the developing brain eye, ear, heart and vascular system.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalGene Expression Patterns
Volume13
Issue number1-2
DOIs
StatePublished - Jan 2013

Fingerprint

Zebrafish
Gene Expression
Pseudopodia
Blister
Cell Adhesion
Polymerization
Cell Movement
Ear
Blood Vessels
Actins
Cell Culture Techniques
Mothers
Genome
Brain

Keywords

  • Actin
  • Brain
  • Otic vesicles
  • Vascular system
  • Visual system

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Developmental Biology
  • Medicine(all)

Cite this

Comparative gene expression analysis of the fmnl family of formins during zebrafish development and implications for tissue specific functions. / Santos-Ledo, Adrián; Jenny, Andreas; Marlow, Florence L.

In: Gene Expression Patterns, Vol. 13, No. 1-2, 01.2013, p. 30-37.

Research output: Contribution to journalArticle

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