TY - JOUR
T1 - Comparative gene expression analysis of the fmnl family of formins during zebrafish development and implications for tissue specific functions
AU - Santos-Ledo, Adrián
AU - Jenny, Andreas
AU - Marlow, Florence L.
N1 - Funding Information:
Research of the Marlow and Jenny labs is funded by grants NIH RO1 GM1089979 (F.L.M.) and RO1 GM088202 (A.J.) and start up funds to FLM and AJ, respectively. We thank the Einstein Cancer Center supported Histopathology resource for use of the cryotome. We thank P. Campbell and Dr. L. Feng for their valuable comments on the manuscript and Marlow and Jenny lab members for discussions.
PY - 2013
Y1 - 2013
N2 - Fmlns belong to the Formin family, catalysts of linear actin polymerization with mostly unknown roles in vivo. In cell culture Fmnls are involved in cell migration and adhesion and the formation of different types of protrusions including filopodia and blebs, suggesting important roles during development. Moreover, Fmnls can act downstream of Rac and Cdc42, mediators of cytoskeletal changes as targets of important pathways required for shaping tissues. The zebrafish genome encodes five Fmnls. Here we report their tissue specific expression patterns during early development and pharyngula stages. The fmnls show overlapping and distinct expression patterns, which suggest that they could regulate similar processes during development, but may also have independent functions. In particular, we find a strong maternal contribution of all fmnls, but distinct expression patterns in the developing brain eye, ear, heart and vascular system.
AB - Fmlns belong to the Formin family, catalysts of linear actin polymerization with mostly unknown roles in vivo. In cell culture Fmnls are involved in cell migration and adhesion and the formation of different types of protrusions including filopodia and blebs, suggesting important roles during development. Moreover, Fmnls can act downstream of Rac and Cdc42, mediators of cytoskeletal changes as targets of important pathways required for shaping tissues. The zebrafish genome encodes five Fmnls. Here we report their tissue specific expression patterns during early development and pharyngula stages. The fmnls show overlapping and distinct expression patterns, which suggest that they could regulate similar processes during development, but may also have independent functions. In particular, we find a strong maternal contribution of all fmnls, but distinct expression patterns in the developing brain eye, ear, heart and vascular system.
KW - Actin
KW - Brain
KW - Otic vesicles
KW - Vascular system
KW - Visual system
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U2 - 10.1016/j.gep.2012.09.002
DO - 10.1016/j.gep.2012.09.002
M3 - Article
C2 - 23072729
AN - SCOPUS:84880165633
SN - 1567-133X
VL - 13
SP - 30
EP - 37
JO - Gene Expression Patterns
JF - Gene Expression Patterns
IS - 1-2
ER -